Seroatlas · Human Serome Atlas

RPS17

Small ribosomal subunit protein eS17

Also known as: MGC72007, RPS17L, RPS17L1, RPS17L2, RS17_HUMAN, S17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08708
Gene
RPS17
Ensembl
ENSG00000182774
Chromosome
15
Canonical length
135 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>P08708|RPS17
     1  MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR
    61  IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT
   121  QPTVGMNFKT PRGPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
4,146 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 4,146 nTPM
  • ovary: 4,137 nTPM
  • bone marrow: 3,595 nTPM
  • skin: 3,409 nTPM
  • esophagus: 3,018 nTPM
  • breast: 2,862 nTPM

Single-cell type

  • gastric chief cells: 3,360 nCPM
  • enteric stem cells: 3,300 nCPM
  • enteric transient amplifying cells: 3,076 nCPM
  • parietal cells: 2,592 nCPM
  • mucous neck cells: 2,326 nCPM
  • paneth cells: 2,259 nCPM

Immune cell

  • total PBMC: 3,346 nTPM
  • memory B-cell: 2,382 nTPM
  • naive CD4 T-cell: 2,288 nTPM
  • naive B-cell: 2,184 nTPM
  • naive CD8 T-cell: 1,993 nTPM
  • memory CD4 T-cell: 1,961 nTPM

Brain region

  • choroid plexus: 453 nTPM
  • white matter: 445 nTPM
  • spinal cord: 435 nTPM
  • medulla oblongata: 422 nTPM
  • hypothalamus: 409 nTPM
  • thalamus: 394 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS17.

Disease | AllUniProt

Conditions RPS17 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0.33
DepMap mean gene effect
-1.55
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein eS17
  • Small ribosomal subunit protein eS17, conserved site
  • Small ribosomal subunit protein eS17 superfamily
  • Ribosomal S17

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS17 as an antibody target. Whether an autoantibody or antibody against RPS17 could matter depends on whether native RPS17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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