Seroatlas · Human Serome Atlas

EIF3L

Eukaryotic translation initiation factor 3 subunit L

Also known as: EIF3EIP, EIF3L_HUMAN, EIF3S11, EIF3S6IP, HSPC021, HSPC025

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y262
Gene
EIF3L
Ensembl
ENSG00000100129
Chromosome
22
Canonical length
564 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>Q9Y262|EIF3L
     1  MSYPADDYES EAAYDPYAYP SDYDMHTGDP KQDLAYERQY EQQTYQVIPE VIKNFIQYFH
    61  KTVSDLIDQK VYELQASRVS SDVIDQKVYE IQDIYENSWT KLTERFFKNT PWPEAEAIAP
   121  QVGNDAVFLI LYKELYYRHI YAKVSGGPSL EQRFESYYNY CNLFNYILNA DGPAPLELPN
   181  QWLWDIIDEF IYQFQSFSQY RCKTAKKSEE EIDFLRSNPK IWNVHSVLNV LHSLVDKSNI
   241  NRQLEVYTSG GDPESVAGEY GRHSLYKMLG YFSLVGLLRL HSLLGDYYQA IKVLENIELN
   301  KKSMYSRVPE CQVTTYYYVG FAYLMMRRYQ DAIRVFANIL LYIQRTKSMF QRTTYKYEMI
   361  NKQNEQMHAL LAIALTMYPM RIDESIHLQL REKYGDKMLR MQKGDPQVYE ELFSYSCPKF
   421  LSPVVPNYDN VHPNYHKEPF LQQLKVFSDE VQQQAQLSTI RSFLKLYTTM PVAKLAGFLD
   481  LTEQEFRIQL LVFKHKMKNL VWTSGISALD GEFQSASEVD FYIDKDMIHI ADTKVARRYG
   541  DFFIRQIHKF EELNRTLKKM GQRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
229 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 229 nTPM
  • ovary: 167 nTPM
  • breast: 140 nTPM
  • skeletal muscle: 137 nTPM
  • stomach: 114 nTPM
  • skin: 106 nTPM

Single-cell type

  • erythrocyte progenitors: 67 nCPM
  • megakaryocyte-erythroid progenitors: 61 nCPM
  • monocyte progenitors: 56 nCPM
  • pancreatic acinar cells: 56 nCPM
  • neutrophil progenitors: 54 nCPM
  • distal convoluted tubule cells: 53 nCPM

Immune cell

  • total PBMC: 297 nTPM
  • myeloid DC: 241 nTPM
  • naive CD4 T-cell: 162 nTPM
  • classical monocyte: 161 nTPM
  • intermediate monocyte: 147 nTPM
  • MAIT T-cell: 134 nTPM

Brain region

  • cerebellum: 21 nTPM
  • white matter: 18 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 17 nTPM
  • midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.84
gnomAD missense Z
2.7
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3L as an antibody target. Whether an autoantibody or antibody against EIF3L could matter depends on whether native EIF3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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