Seroatlas · Human Serome Atlas

QKI

KH domain-containing RNA-binding protein QKI

Also known as: QK3, QKI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PU8
Gene
QKI
Ensembl
ENSG00000112531
Chromosome
6
Canonical length
341 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q96PU8|QKI
     1  MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
    61  LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
   121  IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
   181  PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
   241  LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
   301  LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QKI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
290 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 290 nTPM
  • tongue: 207 nTPM
  • cerebral cortex: 198 nTPM
  • midbrain: 181 nTPM
  • hippocampal formation: 147 nTPM
  • skeletal muscle: 147 nTPM

Single-cell type

  • oligodendrocytes: 5,472 nCPM
  • myonuclei: 3,259 nCPM
  • neutrophils: 3,082 nCPM
  • bergmann glia: 2,279 nCPM
  • oligodendrocyte progenitor cells: 1,948 nCPM
  • microglia: 1,858 nCPM

Immune cell

  • neutrophil: 9.2 nTPM
  • classical monocyte: 7.2 nTPM
  • NK-cell: 6.3 nTPM
  • plasmacytoid DC: 6.2 nTPM
  • non-classical monocyte: 5.1 nTPM
  • intermediate monocyte: 4.7 nTPM

Brain region

  • white matter: 1,466 nTPM
  • medulla oblongata: 1,155 nTPM
  • basal ganglia: 1,106 nTPM
  • midbrain: 980 nTPM
  • thalamus: 968 nTPM
  • cerebellum: 961 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QKI.

Disease | ImmuneIEDB

Conditions an epitope on QKI was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.75
gnomAD missense Z
3.02
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of QKI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QKI as an antibody target. Whether an autoantibody or antibody against QKI could matter depends on whether native QKI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QKI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QKI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QKI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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