Seroatlas · Human Serome Atlas

NUFIP2

FMR1-interacting protein NUFIP2

Also known as: 182-FIP, 82-FIP, FIP-82, KIAA1321, MGC117262, NUFP2, NUFP2_HUMAN, PIG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z417
Gene: NUFIP2
Ensembl: ENSG00000108256
Chromosome: 17
Canonical length: 695 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in several cellular components, including cytoplasmic stress granule; nuclear body; and ribosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

695 residues, UniProt reviewed canonical sequence.

>Q7Z417|NUFIP2
     1  MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH HQQPHQYLQH
    61  GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN AGEREISLKN LSSDEATNPI
   121  SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK TKNFIQKNSM DKKNGKSYEN KSGENQSVDK
   181  SDTIPIPNGV VTNNSGYITN GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV
   241  QDKIMQQETS VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML
   301  RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA KIVPKISYAS
   361  KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ VPMSALKSVT SANFSNGPVL
   421  AGTDGNVYPP GGQPLLTTAA NTLTPISSGT DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT
   481  MLLSTAQVDL PSQTDQQNLG DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY
   541  PATLVSQGAE IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD
   601  LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN DSWGSFDLRA
   661  AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUFIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 75 nTPM
placenta: 28 nTPM
liver: 22 nTPM
appendix: 21 nTPM
retina: 21 nTPM
lung: 20 nTPM

Single-cell type

neutrophils: 461 nCPM
monocyte progenitors: 327 nCPM
syncytiotrophoblasts: 326 nCPM
monocytes: 314 nCPM
neutrophil progenitors: 297 nCPM
endometrial secretory cells: 273 nCPM

Immune cell

neutrophil: 26 nTPM
basophil: 14 nTPM
plasmacytoid DC: 12 nTPM
non-classical monocyte: 9.7 nTPM
eosinophil: 8.5 nTPM
memory B-cell: 8.5 nTPM

Brain region

cerebral cortex: 134 nTPM
hypothalamus: 110 nTPM
midbrain: 101 nTPM
white matter: 95 nTPM
medulla oblongata: 95 nTPM
choroid plexus: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

FMR1-interacting protein 2
FMR1-interacting protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUFIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUFIP2 as an antibody target. Whether an autoantibody or antibody against NUFIP2 could matter depends on whether native NUFIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUFIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUFIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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