Seroatlas · Human Serome Atlas

RPS15A

Small ribosomal subunit protein uS8

Also known as: RS15A_HUMAN, S15A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62244
Gene
RPS15A
Ensembl
ENSG00000134419
Chromosome
16
Canonical length
130 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>P62244|RPS15A
     1  MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
    61  IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
   121  TGGKILGFFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS15A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
3,722 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,722 nTPM
  • breast: 3,710 nTPM
  • bone marrow: 3,363 nTPM
  • pancreas: 2,714 nTPM
  • skin: 2,533 nTPM
  • lymph node: 2,451 nTPM

Single-cell type

  • gastric progenitor cells: 8,414 nCPM
  • decidual stromal cells: 8,261 nCPM
  • extravillous trophoblasts: 7,690 nCPM
  • esophageal suprabasal cells: 7,668 nCPM
  • ovarian stromal cells: 7,561 nCPM
  • esophageal basal cells: 7,224 nCPM

Immune cell

  • total PBMC: 5,386 nTPM
  • naive CD4 T-cell: 3,597 nTPM
  • memory B-cell: 3,147 nTPM
  • memory CD4 T-cell: 2,884 nTPM
  • naive CD8 T-cell: 2,860 nTPM
  • naive B-cell: 2,604 nTPM

Brain region

  • white matter: 237 nTPM
  • spinal cord: 237 nTPM
  • medulla oblongata: 235 nTPM
  • hypothalamus: 226 nTPM
  • choroid plexus: 210 nTPM
  • thalamus: 210 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS15A.

Disease | AllUniProt

Conditions RPS15A is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 39 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 20

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.8
gnomAD missense Z
2.24
DepMap mean gene effect
-2.35
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein uS8
  • Small ribosomal subunit protein uS8 superfamily
  • Small ribosomal subunit protein uS8, conserved site
  • Ribosomal protein S8

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS15A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS15A as an antibody target. Whether an autoantibody or antibody against RPS15A could matter depends on whether native RPS15A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS15A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS15A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS15A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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