Seroatlas · Human Serome Atlas

RPS20

Small ribosomal subunit protein uS10

Also known as: RS20_HUMAN, S20, uS10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60866
Gene
RPS20
Ensembl
ENSG00000008988
Chromosome
8
Canonical length
119 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>P60866|RPS20
     1  MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT
    61  LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ ITSISIEPGV EVEVTIADA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
4,921 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,921 nTPM
  • bone marrow: 4,099 nTPM
  • lymph node: 3,441 nTPM
  • skin: 3,176 nTPM
  • adipose tissue: 3,067 nTPM
  • breast: 3,005 nTPM

Single-cell type

  • esophageal suprabasal cells: 5,362 nCPM
  • extravillous trophoblasts: 5,125 nCPM
  • esophageal basal cells: 5,020 nCPM
  • ovarian stromal cells: 4,958 nCPM
  • esophageal apical cells: 4,607 nCPM
  • decidual stromal cells: 4,333 nCPM

Immune cell

  • total PBMC: 8,791 nTPM
  • naive CD4 T-cell: 5,961 nTPM
  • memory B-cell: 5,496 nTPM
  • naive B-cell: 4,645 nTPM
  • memory CD4 T-cell: 4,610 nTPM
  • naive CD8 T-cell: 4,407 nTPM

Brain region

  • white matter: 691 nTPM
  • spinal cord: 684 nTPM
  • basal ganglia: 598 nTPM
  • medulla oblongata: 593 nTPM
  • thalamus: 578 nTPM
  • hypothalamus: 540 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS20.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 367 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0.02
gnomAD missense Z
1.05
DepMap mean gene effect
-2.66
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS20 as an antibody target. Whether an autoantibody or antibody against RPS20 could matter depends on whether native RPS20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...