Seroatlas · Human Serome Atlas

EIF3I

Eukaryotic translation initiation factor 3 subunit I

Also known as: eIF3-beta, eIF3-p36, EIF3I_HUMAN, EIF3S2, TRIP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13347
Gene
EIF3I
Ensembl
ENSG00000084623
Chromosome
1
Canonical length
325 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q13347|EIF3I
     1  MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA
    61  DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC
   121  FVSFFDLRDP SQIDNNEPYM KIPCNDSKIT SAVWGPLGEC IIAGHESGEL NQYSAKSGEV
   181  LVNVKEHSRQ INDIQLSRDM TMFVTASKDN TAKLFDSTTL EHQKTFRTER PVNSAALSPN
   241  YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY
   301  SSGGEDGYVR IHYFDPQYFE FEFEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3I can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
251 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 251 nTPM
  • tongue: 202 nTPM
  • tonsil: 171 nTPM
  • ovary: 154 nTPM
  • rectum: 149 nTPM
  • thymus: 148 nTPM

Single-cell type

  • esophageal suprabasal cells: 522 nCPM
  • esophageal basal cells: 469 nCPM
  • extravillous trophoblasts: 401 nCPM
  • syncytiotrophoblasts: 385 nCPM
  • migrating cytotrophoblasts: 379 nCPM
  • decidual stromal cells: 375 nCPM

Immune cell

  • total PBMC: 308 nTPM
  • myeloid DC: 246 nTPM
  • T-reg: 238 nTPM
  • intermediate monocyte: 225 nTPM
  • classical monocyte: 204 nTPM
  • NK-cell: 195 nTPM

Brain region

  • white matter: 71 nTPM
  • choroid plexus: 71 nTPM
  • cerebellum: 66 nTPM
  • thalamus: 61 nTPM
  • pons: 60 nTPM
  • spinal cord: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.95
gnomAD missense Z
2.46
DepMap mean gene effect
-1.69
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3I in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3I as an antibody target. Whether an autoantibody or antibody against EIF3I could matter depends on whether native EIF3I is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3I is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3I as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3I. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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