Seroatlas · Human Serome Atlas

RPLP0

Large ribosomal subunit protein uL10

Also known as: L10E, LP0, P0, PRLP0, RLA0_HUMAN, RPP0

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05388
Gene
RPLP0
Ensembl
ENSG00000089157
Chromosome
12
Canonical length
317 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>P05388|RPLP0
     1  MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK AVVLMGKNTM
    61  MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD MLLANKVPAA ARAGAIAPCE
   121  VTVPAQNTGL GPEKTSFFQA LGITTKISRG TIEILSDVQL IKTGDKVGAS EATLLNMLNI
   181  SPFSFGLVIQ QVFDNGSIYN PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS
   241  IINGYKRVLA LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA
   301  KEESEESDED MGFGLFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPLP0 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
4,457 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 4,457 nTPM
  • ovary: 3,403 nTPM
  • esophagus: 3,182 nTPM
  • skin: 3,125 nTPM
  • bone marrow: 3,096 nTPM
  • skeletal muscle: 2,801 nTPM

Single-cell type

  • extravillous trophoblasts: 7,012 nCPM
  • decidual stromal cells: 6,018 nCPM
  • esophageal apical cells: 5,804 nCPM
  • migrating cytotrophoblasts: 5,562 nCPM
  • esophageal suprabasal cells: 5,438 nCPM
  • esophageal basal cells: 4,240 nCPM

Immune cell

  • total PBMC: 7,077 nTPM
  • MAIT T-cell: 4,007 nTPM
  • plasmacytoid DC: 3,813 nTPM
  • memory B-cell: 3,726 nTPM
  • naive B-cell: 3,471 nTPM
  • myeloid DC: 3,462 nTPM

Brain region

  • medulla oblongata: 397 nTPM
  • choroid plexus: 388 nTPM
  • thalamus: 368 nTPM
  • spinal cord: 368 nTPM
  • white matter: 363 nTPM
  • hypothalamus: 329 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPLP0.

Disease | ImmuneIEDB

Conditions an epitope on RPLP0 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.77
gnomAD missense Z
1.62
DepMap mean gene effect
-1.52
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPLP0 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPLP0 as an antibody target. Whether an autoantibody or antibody against RPLP0 could matter depends on whether native RPLP0 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPLP0 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPLP0 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPLP0. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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