Seroatlas · Human Serome Atlas

STYXL1

Serine/threonine/tyrosine-interacting-like protein 1

Also known as: DUSP24, MK-STYX, STYL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6J8
Gene: STYXL1
Ensembl: ENSG00000127952
Chromosome: 7
Canonical length: 313 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein phosphatase binding activity and pseudophosphatase activity. Involved in negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of neuron projection development. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9Y6J8|STYXL1
     1  MPGLLLCEPT ELYNILNQAT KLSRLTDPNY LCLLDVRSKW EYDESHVITA LRVKKKNNEY
    61  LLPESVDLEC VKYCVVYDNN SSTLEILLKD DDDDSDSDGD GKDLVPQAAI EYGRILTRLT
   121  HHPVYILKGG YERFSGTYHF LRTQKIIWMP QELDAFQPYP IEIVPGKVFV GNFSQACDPK
   181  IQKDLKIKAH VNVSMDTGPF FAGDADKLLH IRIEDSPEAQ ILPFLRHMCH FIEIHHHLGS
   241  VILIFSTQGI SRSCAAIIAY LMHSNEQTLQ RSWAYVKKCK NNMCPNRGLV SQLLEWEKTI
   301  LGDSITNIMD PLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STYXL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 43 nTPM
fallopian tube: 27 nTPM
pancreas: 21 nTPM
testis: 21 nTPM
tonsil: 20 nTPM
epididymis: 20 nTPM

Single-cell type

esophageal apical cells: 171 nCPM
late primary spermatocytes: 116 nCPM
respiratory ciliated cells: 93 nCPM
fallopian tube ciliated cells: 87 nCPM
early spermatids: 85 nCPM
late spermatids: 82 nCPM

Immune cell

basophil: 71 nTPM
classical monocyte: 53 nTPM
eosinophil: 50 nTPM
NK-cell: 50 nTPM
intermediate monocyte: 48 nTPM
non-classical monocyte: 47 nTPM

Brain region

choroid plexus: 24 nTPM
white matter: 21 nTPM
basal ganglia: 19 nTPM
pons: 18 nTPM
cerebral cortex: 18 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dual specificity phosphatase, catalytic domain
Rhodanese-like domain
Dual specificity protein phosphatase domain
Protein-tyrosine phosphatase-like
Rhodanese-like domain superfamily
Rhodanese-like domain
Dual specificity phosphatase, catalytic domain
Serine/threonine/tyrosine-interacting-like protein

KeywordsUniProt

Mitochondrion

InteractionsUniProt · HPA

Protein binding partners of STYXL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STYXL1 as an antibody target. Whether an autoantibody or antibody against STYXL1 could matter depends on whether native STYXL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STYXL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STYXL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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