Seroatlas · Human Serome Atlas

RPL10

Large ribosomal subunit protein uL16

Also known as: DXS648, DXS648E, FLJ23544, L10, NOV, QM, RL10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P27635
Gene
RPL10
Ensembl
ENSG00000147403
Chromosome
X
Canonical length
214 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>P27635|RPL10
     1  MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL
    61  SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
   121  KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
   181  FEDMVAEKRL IPDGCGVKYI PSRGPLDKWR ALHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
7,891 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 7,891 nTPM
  • ovary: 7,828 nTPM
  • tonsil: 4,943 nTPM
  • skeletal muscle: 4,611 nTPM
  • breast: 4,519 nTPM
  • bone marrow: 4,381 nTPM

Single-cell type

  • decidual stromal cells: 20,461 nCPM
  • esophageal apical cells: 13,891 nCPM
  • ovarian stromal cells: 13,873 nCPM
  • esophageal suprabasal cells: 13,636 nCPM
  • pancreatic acinar cells: 13,164 nCPM
  • breast secretory cells: 13,009 nCPM

Immune cell

  • total PBMC: 18,216 nTPM
  • naive CD4 T-cell: 9,025 nTPM
  • memory B-cell: 8,155 nTPM
  • MAIT T-cell: 7,792 nTPM
  • naive B-cell: 7,735 nTPM
  • memory CD4 T-cell: 7,559 nTPM

Brain region

  • spinal cord: 814 nTPM
  • white matter: 805 nTPM
  • medulla oblongata: 723 nTPM
  • thalamus: 648 nTPM
  • hypothalamus: 629 nTPM
  • pons: 593 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL10.

Disease | AllUniProt

Conditions RPL10 is implicated in, by any mechanism.

  • Autism, X-linked 5 (AUTSX5) MIM:300847
  • Intellectual developmental disorder, X-linked, syndromic 35 (MRXS35) MIM:300998

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual disability, X-linked, syndromic, 35

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
2.61
DepMap mean gene effect
-0.88
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL10 as an antibody target. Whether an autoantibody or antibody against RPL10 could matter depends on whether native RPL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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