Seroatlas · Human Serome Atlas

RPL6

Large ribosomal subunit protein eL6

Also known as: L6, RL6_HUMAN, TAXREB107, TXREB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02878
Gene
RPL6
Ensembl
ENSG00000089009
Chromosome
12
Canonical length
288 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q02878|RPL6
     1  MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS
    61  AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED
   121  VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV
   181  LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY
   241  EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
2,703 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,703 nTPM
  • bone marrow: 2,251 nTPM
  • tonsil: 2,064 nTPM
  • pancreas: 1,955 nTPM
  • breast: 1,735 nTPM
  • lymph node: 1,727 nTPM

Single-cell type

  • decidual stromal cells: 6,336 nCPM
  • esophageal suprabasal cells: 5,448 nCPM
  • extravillous trophoblasts: 5,036 nCPM
  • esophageal basal cells: 4,520 nCPM
  • ovarian stromal cells: 4,013 nCPM
  • migrating cytotrophoblasts: 4,000 nCPM

Immune cell

  • total PBMC: 7,780 nTPM
  • MAIT T-cell: 3,822 nTPM
  • naive CD4 T-cell: 3,763 nTPM
  • memory B-cell: 3,476 nTPM
  • memory CD4 T-cell: 3,475 nTPM
  • plasmacytoid DC: 3,379 nTPM

Brain region

  • choroid plexus: 448 nTPM
  • spinal cord: 441 nTPM
  • white matter: 426 nTPM
  • hypothalamus: 423 nTPM
  • midbrain: 410 nTPM
  • medulla oblongata: 408 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
0.99
gnomAD missense Z
1.03
DepMap mean gene effect
-2.33
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL6 as an antibody target. Whether an autoantibody or antibody against RPL6 could matter depends on whether native RPL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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