Seroatlas · Human Serome Atlas

RPS5

Small ribosomal subunit protein uS7

Also known as: RS5_HUMAN, S5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46782
Gene
RPS5
Ensembl
ENSG00000083845
Chromosome
19
Canonical length
204 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>P46782|RPS5
     1  MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR
    61  FRKAQCPIVE RLTNSMMMHG RNNGKKLMTV RIVKHAFEII HLLTGENPLQ VLVNAIINSG
   121  PREDSTRIGR AGTVRRQAVD VSPLRRVNQA IWLLCTGARE AAFRNIKTIA ECLADELINA
   181  AKGSSNSYAI KKKDELERVA KSNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
2,780 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 2,780 nTPM
  • ovary: 2,360 nTPM
  • skin: 1,963 nTPM
  • esophagus: 1,523 nTPM
  • bone marrow: 1,517 nTPM
  • skeletal muscle: 1,408 nTPM

Single-cell type

  • esophageal suprabasal cells: 7,374 nCPM
  • esophageal basal cells: 6,655 nCPM
  • esophageal apical cells: 6,055 nCPM
  • decidual stromal cells: 5,984 nCPM
  • pancreatic acinar cells: 5,869 nCPM
  • breast secretory cells: 5,236 nCPM

Immune cell

  • total PBMC: 2,586 nTPM
  • memory B-cell: 2,229 nTPM
  • naive B-cell: 2,082 nTPM
  • naive CD4 T-cell: 1,836 nTPM
  • naive CD8 T-cell: 1,440 nTPM
  • MAIT T-cell: 1,363 nTPM

Brain region

  • spinal cord: 369 nTPM
  • thalamus: 339 nTPM
  • medulla oblongata: 325 nTPM
  • white matter: 317 nTPM
  • basal ganglia: 313 nTPM
  • pons: 292 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
gnomAD missense Z
2.79
DepMap mean gene effect
-1.78
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS5 as an antibody target. Whether an autoantibody or antibody against RPS5 could matter depends on whether native RPS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...