Seroatlas · Human Serome Atlas

RPS11

Small ribosomal subunit protein uS17

Also known as: RS11_HUMAN, S11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62280
Gene
RPS11
Ensembl
ENSG00000142534
Chromosome
19
Canonical length
158 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>P62280|RPS11
     1  MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA IEGTYIDKKC
    61  PFTGNVSIRG RILSGVVTKM KMQRTIVIRR DYLHYIRKYN RFEKRHKNMS VHLSPCFRDV
   121  QIGDIVTVGE CRPLSKTVRF NVLKVTKAAG TKKQFQKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
6,630 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 6,630 nTPM
  • bone marrow: 4,836 nTPM
  • tonsil: 4,446 nTPM
  • breast: 4,090 nTPM
  • skin: 4,084 nTPM
  • cervix: 3,796 nTPM

Single-cell type

  • esophageal suprabasal cells: 5,054 nCPM
  • extravillous trophoblasts: 4,703 nCPM
  • esophageal basal cells: 4,348 nCPM
  • decidual stromal cells: 3,640 nCPM
  • esophageal apical cells: 3,626 nCPM
  • suprabasal keratinocytes: 3,539 nCPM

Immune cell

  • total PBMC: 6,126 nTPM
  • memory B-cell: 4,905 nTPM
  • naive B-cell: 4,604 nTPM
  • plasmacytoid DC: 3,740 nTPM
  • naive CD4 T-cell: 3,199 nTPM
  • myeloid DC: 2,984 nTPM

Brain region

  • spinal cord: 1,016 nTPM
  • white matter: 972 nTPM
  • medulla oblongata: 944 nTPM
  • thalamus: 941 nTPM
  • basal ganglia: 905 nTPM
  • hypothalamus: 889 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS11.

Disease | ImmuneIEDB

Conditions an epitope on RPS11 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.94
gnomAD missense Z
1.61
DepMap mean gene effect
-2.51
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS11 as an antibody target. Whether an autoantibody or antibody against RPS11 could matter depends on whether native RPS11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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