Nuclear transport factor 2 domain

Definition

This entry represent the main structural domain of NTF2, Nuclear RNA export factors and related proteins [[cite:PMID:11583626], [cite:PMID:11846560]]. Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity PMID:9533885.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• G3BP1
• G3BP2
• NUTF2
• NXF1
• NXF2
• NXF3
• NXF5
• NXT1
• NXT2