Seroatlas · Human Serome Atlas

UBAP2L

Ubiquitin-associated protein 2-like

Also known as: KIAA0144, NICE-4, UBP2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14157
Gene: UBAP2L
Ensembl: ENSG00000143569
Chromosome: 1
Canonical length: 1087 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in binding activity of sperm to zona pellucida; positive regulation of stress granule assembly; and stress granule assembly. Acts upstream of or within hematopoietic stem cell homeostasis. Part of PcG protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1087 residues, UniProt reviewed canonical sequence.

>Q14157|UBAP2L
     1  MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF EEKVKQLIDI
    61  TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG KKKGVSGQKD GGQTESNEEG
   121  KENRDRDRDY SRRRGGPPRR GRGASRGREF RGQENGLDGT KSGGPSGRGT ERGRRGRGRG
   181  RGGSGRRGGR FSAQGMGTFN PADYAEPANT DDNYGNSSGN TWNNTGHFEP DDGTSAWRTA
   241  TEEWGTEDWN EDLSETKIFT ASNVSSVPLP AENVTITAGQ RIDLAVLLGK TPSTMENDSS
   301  NLDPSQAPSL AQPLVFSNSK QTAISQPASG NTFSHHSMVS MLGKGFGDVG EAKGGSTTGS
   361  QFLEQFKTAQ ALAQLAAQHS QSGSTTTSSW DMGSTTQSPS LVQYDLKNPS DSAVHSPFTK
   421  RQAFTPSSTM MEVFLQEKSP AVATSTAAPP PPSSPLPSKS TSAPQMSPGS SDNQSSSPQP
   481  AQQKLKQQKK KASLTSKIPA LAVEMPGSAD ISGLNLQFGA LQFGSEPVLS DYESTPTTSA
   541  SSSQAPSSLY TSTASESSST ISSNQSQESG YQSGPIQSTT YTSQNNAQGP LYEQRSTQTR
   601  RYPSSISSSP QKDLTQAKNG FSSVQATQLQ TTQSVEGATG SAVKSDSPST SSIPPLNETV
   661  SAASLLTTTN QHSSSLGGLS HSEEIPNTTT TQHSSTLSTQ QNTLSSSTSS GRTSTSTLLH
   721  TSVESEANLH SSSSTFSTTS STVSAPPPVV SVSSSLNSGS SLGLSLGSNS TVTASTRSSV
   781  ATTSGKAPPN LPPGVPPLLP NPYIMAPGLL HAYPPQVYGY DDLQMLQTRF PLDYYSIPFP
   841  TPTTPLTGRD GSLASNPYSG DLTKFGRGDA SSPAPATTLA QPQQNQTQTH HTTQQTFLNP
   901  ALPPGYSYTS LPYYTGVPGL PSTFQYGPAV FPVAPTSSKQ HGVNVSVNAS ATPFQQPSGY
   961  GSHGYNTGVS VTSSNTGVPD ISGSVYSKTQ QSFEKQGFHS GTPAASFNLP SALGSGGPIN
  1021  PATAAAYPPA PFMHILTPHQ QPHSQILHHH LQQDGQTGSG QRSQTSSIPQ KPQTNKSAYN
  1081  SYSWGAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBAP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 75 nTPM
placenta: 66 nTPM
tonsil: 62 nTPM
testis: 60 nTPM
bone marrow: 59 nTPM
heart muscle: 59 nTPM

Single-cell type

cardiomyocytes: 313 nCPM
epicardial cells: 248 nCPM
late spermatids: 226 nCPM
neutrophils: 131 nCPM
early spermatids: 118 nCPM
syncytiotrophoblasts: 106 nCPM

Immune cell

non-classical monocyte: 42 nTPM
NK-cell: 37 nTPM
intermediate monocyte: 36 nTPM
myeloid DC: 35 nTPM
total PBMC: 30 nTPM
classical monocyte: 28 nTPM

Brain region

cerebral cortex: 139 nTPM
white matter: 85 nTPM
choroid plexus: 83 nTPM
hypothalamus: 79 nTPM
amygdala: 78 nTPM
basal ganglia: 77 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBAP2L.

Disease | AllUniProt

Conditions UBAP2L is implicated in, by any mechanism.

Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies (NEDLBF) MIM:620494

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 200 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies
Neurodevelopmental abnormality

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 3.34
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBAP2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBAP2L as an antibody target. Whether an autoantibody or antibody against UBAP2L could matter depends on whether native UBAP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBAP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBAP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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