Seroatlas · Protein domains

Galactose-binding-like domain superfamily

IPR008979

Definition

Proteins containing a galactose-binding-like domain fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase PMID:2002850, phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va PMID:10586886, membrane-anchored ephrin for the Eph family of receptor tyrosine kinases PMID:11780069, and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 PMID:10467102. The structure of the galactose-binding-like domain members consists of a β-sandwich, in which the strands making up the sheets exhibit a jelly roll fold. There is a high degree of similarity in the β-sandwich and in the loops between different family members, despite an often low level of sequence similarity.

77 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (77 proteins: gene, accession, name)

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