FBXO17

Protein identityUniProt · HPA

UniProt accession

Q96EF6

Gene

FBXO17

Ensembl

ENSG00000269190

Chromosome

19

Canonical length

278 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q96EF6|FBXO17
     1  MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR DIVDGPTVWL
    61  LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR
   121  GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE
   181  ICVADWWGAR ENCGCVYQLR VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG
   241  KGIRYVSFEQ YGRDVSSWVG HYGALVTHSS VRVRIRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

71 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.77

gnomAD pLI

0

gnomAD missense Z

0.21

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ERAD pathway
• glycoprotein catabolic process
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

• cytoplasm
• cytosol
• SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• F-box associated (FBA) domain
• Galactose-binding-like domain superfamily
• F-box-like domain superfamily
• F-box only protein
• F-box associated region
• F-box-like

KeywordsUniProt

• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• SKP1
• COPS3
• COPS4
• COPS5
• COPS6