Seroatlas · Human Serome Atlas

XNDC1N

Protein XNDC1N

Also known as: XNDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNB5
Gene: XNDC1N
Ensembl: ENSG00000254469
Chromosome: 11
Canonical length: 234 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic chromosome

OverviewNCBI Gene

Predicted to enable damaged DNA binding activity. Predicted to be involved in single strand break repair. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q6ZNB5|XNDC1N
     1  MAPVKISHVV SFSSQDPKYP VENLLNPDSP RRPWLGCPQD KSGQLKVELQ LERAVPTGYI
    61  DVGNCGCAFL QIDVGHSSWP LDRPFITLLP ATTLMSLTDS KQGKNRSGVR MFKDVDFLAP
   121  ASGELWDRLR LTCSRPFTRH QSFGLAFLRV CSSLDSLDDS VVGPSALLSS VLNKIREFKT
   181  CFFSWSLKKM ELEFSPLLLS INLNDLQFAA DAEVSTVSNC MFISIALQSA MIIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XNDC1N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

retina: 8.3 nTPM
bone marrow: 4.1 nTPM
epididymis: 3.6 nTPM
skin: 3.6 nTPM
lymph node: 3.5 nTPM
ovary: 3.2 nTPM

Single-cell type

renal connecting tubule cells: 84 nCPM
loop of henle epithelial cells: 81 nCPM
renal collecting duct intercalated cells: 79 nCPM
renal collecting duct principal cells: 75 nCPM
proximal tubule cells: 73 nCPM
distal convoluted tubule cells: 70 nCPM

Immune cell

memory CD4 T-cell: 4.7 nTPM
T-reg: 4.7 nTPM
naive CD4 T-cell: 4.4 nTPM
plasmacytoid DC: 4.4 nTPM
naive CD8 T-cell: 3.9 nTPM
memory CD8 T-cell: 3.6 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 19 nTPM
choroid plexus: 17 nTPM
cerebral cortex: 16 nTPM
pons: 16 nTPM
thalamus: 16 nTPM

OntologyGO

Biological processes

single strand break repair

Molecular functions

damaged DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XNDC1N as an antibody target. Whether an autoantibody or antibody against XNDC1N could matter depends on whether native XNDC1N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XNDC1N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XNDC1N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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