FBXO44

Protein identityUniProt · HPA

UniProt accession

Q9H4M3

Gene

FBXO44

Ensembl

ENSG00000132879

Chromosome

1

Canonical length

255 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q9H4M3|FBXO44
     1  MAVGNINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLVTLWKRK CLREGFITED
    61  WDQPVADWKI FYFLRSLHRN LLHNPCAEEG FEFWSLDVNG GDEWKVEDLS RDQRKEFPND
   121  QVKKYFVTSY YTCLKSQVVD LKAEGYWEEL MDTTRPDIEV KDWFAARPDC GSKYQLCVQL
   181  LSSAHAPLGT FQPDPATIQQ KSDAKWREVS HTFSNYPPGV RYIWFQHGGV DTHYWAGWYG
   241  PRVTNSSITI GPPLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

260 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0

gnomAD missense Z

0.35

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ERAD pathway
• glycoprotein catabolic process
• proteasomal protein catabolic process
• proteasome-mediated ubiquitin-dependent protein catabolic process
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Molecular functions

• ubiquitin-like ligase-substrate adaptor activity

Cellular components

• cytoplasm
• cytosol
• nucleus
• SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• F-box associated (FBA) domain
• Galactose-binding-like domain superfamily
• F-box-like domain superfamily
• F-box only protein
• F-box associated region
• F-box-like

KeywordsUniProt

• Nucleus
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• CUL4B
• DDB1
• RGS2
• SKP1
• NR1I2
• BRCA1