Seroatlas · Human Serome Atlas

DCBLD2

Discoidin, CUB and LCCL domain-containing protein 2

Also known as: CLCP1, DCBD2_HUMAN, ESDN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PD2
Gene
DCBLD2
Ensembl
ENSG00000057019
Chromosome
3
Canonical length
775 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Involved in negative regulation of cell growth and wound healing. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

775 residues, UniProt reviewed canonical sequence.

>Q96PD2|DCBLD2
     1  MASRAVVRAR RCPQCPQVRA AAAAPAWAAL PLSRSLPPCS NSSSFSMPLF LLLLLVLLLL
    61  LEDAGAQQGD GCGHTVLGPE SGTLTSINYP QTYPNSTVCE WEIRVKMGER VRIKFGDFDI
   121  EDSDSCHFNY LRIYNGIGVS RTEIGKYCGL GLQMNHSIES KGNEITLLFM SGIHVSGRGF
   181  LASYSVIDKQ DLITCLDTAS NFLEPEFSKY CPAGCLLPFA EISGTIPHGY RDSSPLCMAG
   241  VHAGVVSNTL GGQISVVISK GIPYYESSLA NNVTSVVGHL STSLFTFKTS GCYGTLGMES
   301  GVIADPQITA SSVLEWTDHT GQENSWKPKK ARLKKPGPPW AAFATDEYQW LQIDLNKEKK
   361  ITGIITTGST MVEHNYYVSA YRILYSDDGQ KWTVYREPGV EQDKIFQGNK DYHQDVRNNF
   421  LPPIIARFIR VNPTQWQQKI AMKMELLGCQ FIPKGRPPKL TQPPPPRNSN DLKNTTAPPK
   481  IAKGRAPKFT QPLQPRSSNE FPAQTEQTTA SPDIRNTTVT PNVTKDVALA AVLVPVLVMV
   541  LTTLILILVC AWHWRNRKKK TEGTYDLPYW DRAGWWKGMK QFLPAKAVDH EETPVRYSSS
   601  EVNHLSPREV TTVLQADSAE YAQPLVGGIV GTLHQRSTFK PEEGKEAGYA DLDPYNSPGQ
   661  EVYHAYAEPL PITGPEYATP IIMDMSGHPT TSVGQPSTST FKATGNQPPP LVGTYNTLLS
   721  RTDSCSSAQA QYDTPKAGKP GLPAPDELVY QVPQSTQEVS GAGRDGECDV FKEIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCBLD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 26 nTPM
  • testis: 22 nTPM
  • retina: 21 nTPM
  • ovary: 20 nTPM
  • smooth muscle: 15 nTPM
  • thyroid gland: 15 nTPM

Single-cell type

  • sertoli cells: 479 nCPM
  • bergmann glia: 222 nCPM
  • podocytes: 219 nCPM
  • cone photoreceptor cells: 201 nCPM
  • fibro-adipogenic progenitors: 179 nCPM
  • ocular epithelial cells: 169 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • pons: 61 nTPM
  • cerebellum: 20 nTPM
  • thalamus: 19 nTPM
  • medulla oblongata: 18 nTPM
  • choroid plexus: 17 nTPM
  • hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.1
gnomAD missense Z
0.95
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCBLD2 as an antibody target. Whether an autoantibody or antibody against DCBLD2 could matter depends on whether native DCBLD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCBLD2 is annotated at the cell surface, where native DCBLD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DCBLD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCBLD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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