DDR1

Protein identityUniProt · HPA

UniProt accession

Q08345

Gene

DDR1

Ensembl

ENSG00000204580

Chromosome

6

Canonical length

913 aa

Protein class

CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

913 residues, UniProt reviewed canonical sequence.

>Q08345|DDR1
     1  MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR
    61  HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL
   121  RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV
   181  ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD
   241  FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG
   301  VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS
   361  EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI
   421  GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE
   481  PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT
   541  QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP
   601  PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD
   661  ATKNARNDFL KEVKIMSRLK DPNIIRLLGV CVQDDPLCMI TDYMENGDLN QFLSAHQLED
   721  KAAEGAPGDG QAAQGPTISY PMLLHVAAQI ASGMRYLATL NFVHRDLATR NCLVGENFTI
   781  KIADFGMSRN LYAGDYYRVQ GRAVLPIRWM AWECILMGKF TTASDVWAFG VTLWEVLMLC
   841  RAQPFGQLTD EQVIENAGEF FRDQGRQVYL SRPPACPQGL YELMLRCWSR ESEQRPPFSQ
   901  LHRFLAEDAL NTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

168 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDR1.

Disease | ImmuneIEDB

Conditions an epitope on DDR1 was assayed in.

• prostate cancer T cell
• breast cancer T cell
• ovarian cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.58

gnomAD pLI

0

gnomAD missense Z

2.22

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon development
• branching involved in mammary gland duct morphogenesis
• cell adhesion
• cell population proliferation
• cell surface receptor protein tyrosine kinase signaling pathway
• collagen-activated tyrosine kinase receptor signaling pathway
• ear development
• embryo implantation
• lactation
• mammary gland alveolus development
• negative regulation of cell population proliferation
• neuron projection extension
• peptidyl-tyrosine autophosphorylation
• positive regulation of neuron projection development
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• protein autophosphorylation
• regulation of cell growth
• regulation of cell-matrix adhesion
• regulation of extracellular matrix disassembly
• smooth muscle cell migration
• smooth muscle cell-matrix adhesion
• wound healing, spreading of cells

Molecular functions

• ATP binding
• collagen binding
• metal ion binding
• protein tyrosine kinase collagen receptor activity
• transmembrane receptor protein tyrosine kinase activity

Cellular components

• extracellular exosome
• extracellular space
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Coagulation factor 5/8, C-terminal domain
• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase, receptor class II, conserved site
• Tyrosine-protein kinase, active site
• Galactose-binding-like domain superfamily
• Protein kinase-like domain superfamily
• Tyrosine-protein kinase, catalytic domain
• Discoidin domain-containing receptor 1/2, DS-like domain
• Receptor Tyrosine Kinase
• F5/8 type C domain
• Protein tyrosine and serine/threonine kinase
• Discoidin domain-containing receptor 1/2, DS-like domain

KeywordsUniProt

• ATP-binding
• Calcium
• Cell membrane
• Disulfide bond
• Glycoprotein
• Kinase
• Lactation
• Membrane
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Pregnancy
• Receptor
• Secreted
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of DDR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDH1
• MYH9
• NCK2
• PTPN11
• SRC
• DDR2
• RGS2