FBXO2

Protein identityUniProt · HPA

UniProt accession

Q9UK22

Gene

FBXO2

Ensembl

ENSG00000116661

Chromosome

1

Canonical length

296 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q9UK22|FBXO2
     1  MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA
    61  ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR
   121  RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ
   181  VIDLQAEGYW EELLDTTQPA IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA
   241  VPQDSDGGGW MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

374 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

0.09

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ERAD pathway
• glycoprotein catabolic process
• negative regulation of cell population proliferation
• protein modification process
• protein ubiquitination
• proteolysis
• regulation of protein catabolic process at postsynapse, modulating synaptic transmission
• regulation of protein ubiquitination
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Molecular functions

• amyloid-beta binding
• carbohydrate binding
• denatured protein binding
• ubiquitin-protein transferase activity

Cellular components

• cytoplasm
• cytosol
• dendritic spine
• extrinsic component of postsynaptic membrane
• glutamatergic synapse
• SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• F-box associated (FBA) domain
• Galactose-binding-like domain superfamily
• F-box-like domain superfamily
• F-box only protein
• F-box associated region
• F-box-like

KeywordsUniProt

• Cytoplasm
• Endoplasmic reticulum
• Lectin
• Membrane
• Microsome
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SKP1