Seroatlas · Human Serome Atlas

CPXM2

Inactive carboxypeptidase-like protein X2

Also known as: CPX2, CPXM2_HUMAN, UNQ676

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N436
Gene: CPXM2
Ensembl: ENSG00000121898
Chromosome: 10
Canonical length: 756 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>Q8N436|CPXM2
     1  MSRPGTATPA LALVLLAVTL AGVGAQGAAL EDPDYYGQEI WSREPYYARP EPELETFSPP
    61  LPAGPGEEWE RRPQEPRPPK RATKPKKAPK REKSAPEPPP PGKHSNKKVM RTKSSEKAAN
   121  DDHSVRVARE DVRESCPPLG LETLKITDFQ LHASTVKRYG LGAHRGRLNI QAGINENDFY
   181  DGAWCAGRND LQQWIEVDAR RLTRFTGVIT QGRNSLWLSD WVTSYKVMVS NDSHTWVTVK
   241  NGSGDMIFEG NSEKEIPVLN ELPVPMVARY IRINPQSWFD NGSICMRMEI LGCPLPDPNN
   301  YYHRRNEMTT TDDLDFKHHN YKEMRQLMKV VNEMCPNITR IYNIGKSHQG LKLYAVEISD
   361  HPGEHEVGEP EFHYIAGAHG NEVLGRELLL LLVQFVCQEY LARNARIVHL VEETRIHVLP
   421  SLNPDGYEKA YEGGSELGGW SLGRWTHDGI DINNNFPDLN TLLWEAEDRQ NVPRKVPNHY
   481  IAIPEWFLSE NATVAAETRA VIAWMEKIPF VLGGNLQGGE LVVAYPYDLV RSPWKTQEHT
   541  PTPDDHVFRW LAYSYASTHR LMTDARRRVC HTEDFQKEEG TVNGASWHTV AGSLNDFSYL
   601  HTNCFELSIY VGCDKYPHES QLPEEWENNR ESLIVFMEQV HRGIKGLVRD SHGKGIPNAI
   661  ISVEGINHDI RTANDGDYWR LLNPGEYVVT AKAEGFTAST KNCMVGYDMG ATRCDFTLSK
   721  TNMARIREIM EKFGKQPVSL PARRLKLRGQ KRRQRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPXM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 199 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 199 nTPM
choroid plexus: 177 nTPM
colon: 72 nTPM
epididymis: 57 nTPM
smooth muscle: 53 nTPM
ovary: 45 nTPM

Single-cell type

late spermatids: 563 nCPM
choroid plexus epithelial cells: 337 nCPM
distal convoluted tubule cells: 258 nCPM
early spermatids: 210 nCPM
epididymal principal cells: 145 nCPM
peritubular myoid cells: 140 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 172 nTPM
spinal cord: 43 nTPM
white matter: 38 nTPM
medulla oblongata: 35 nTPM
midbrain: 23 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPXM2 as an antibody target. Whether an autoantibody or antibody against CPXM2 could matter depends on whether native CPXM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPXM2 is annotated as secreted, so native CPXM2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CPXM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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