Seroatlas · Human Serome Atlas

NCCRP1

F-box only protein 50

Also known as: FBX50_HUMAN, FBXO50, LOC342897, NCCRP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVX7
Gene: NCCRP1
Ensembl: ENSG00000188505
Chromosome: 19
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to contribute to ubiquitin protein ligase activity. Involved in positive regulation of cell population proliferation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q6ZVX7|NCCRP1
     1  MEEVREGHAL GGGMEADGPA SLQELPPSPR SPSPPPSPPP LPSPPSLPSP AAPEAPELPE
    61  PAQPSEAHAR QLLLEEWGPL SGGLELPQRL TWKLLLLRRP LYRNLLRSPN PEGINIYEPA
   121  PPTGPTQRPL ETLGNFRGWY IRTEKLQQNQ SWTVKQQCVD LLAEGLWEEL LDDEQPAITV
   181  MDWFEDSRLD ACVYELHVWL LAADRRTVIA QHHVAPRTSG RGPPGRWVQV SHVFRHYGPG
   241  VRFIHFLHKA KNRMEPGGLR RTRVTDSSVS VQLRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCCRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 440 nTPM

Expression across tissuesHPA

Tissue

esophagus: 440 nTPM
skin: 261 nTPM
vagina: 171 nTPM
cervix: 144 nTPM
tonsil: 117 nTPM
salivary gland: 48 nTPM

Single-cell type

esophageal apical cells: 6,313 nCPM
esophageal suprabasal cells: 217 nCPM
suprabasal keratinocytes: 100 nCPM
salivary duct cells: 74 nCPM
retinal pigment epithelial cells: 55 nCPM
prostatic club cells: 28 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebellum: 9.6 nTPM
cerebral cortex: 9.3 nTPM
amygdala: 8.7 nTPM
white matter: 8.7 nTPM
pons: 8.6 nTPM
thalamus: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCCRP1 as an antibody target. Whether an autoantibody or antibody against NCCRP1 could matter depends on whether native NCCRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCCRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCCRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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