Seroatlas · Human Serome Atlas

SUCO

SUN domain-containing ossification factor

Also known as: C1orf9, CH1, OPT, SLP1, SUCO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBS9
Gene: SUCO
Ensembl: ENSG00000094975
Chromosome: 1
Canonical length: 1254 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1254 residues, UniProt reviewed canonical sequence.

>Q9UBS9|SUCO
     1  MKKHRRALAL VSCLFLCSLV WLPSWRVCCK ESSSASASSY YSQDDNCALE NEDVQFQKKD
    61  EREGPINAES LGKSGSNLPI SPKEHKLKDD SIVDVQNTES KKLSPPVVET LPTVDLHEES
   121  SNAVVDSETV ENISSSSTSE ITPISKLDEI EKSGTIPIAK PSETEQSETD CDVGEALDAS
   181  APIEQPSFVS PPDSLVGQHI ENVSSSHGKG KITKSEFESK VSASEQGGGD PKSALNASDN
   241  LKNESSDYTK PGDIDPTSVA SPKDPEDIPT FDEWKKKVME VEKEKSQSMH ASSNGGSHAT
   301  KKVQKNRNNY ASVECGAKIL AANPEAKSTS AILIENMDLY MLNPCSTKIW FVIELCEPIQ
   361  VKQLDIANYE LFSSTPKDFL VSISDRYPTN KWIKLGTFHG RDERNVQSFP LDEQMYAKYV
   421  KMFIKYIKVE LLSHFGSEHF CPLSLIRVFG TSMVEEYEEI ADSQYHSERQ ELFDEDYDYP
   481  LDYNTGEDKS SKNLLGSATN AILNMVNIAA NILGAKTEDL TEGNKSISEN ATATAAPKMP
   541  ESTPVSTPVP SPEYVTTEVH THDMEPSTPD TPKESPIVQL VQEEEEEASP STVTLLGSGE
   601  QEDESSPWFE SETQIFCSEL TTICCISSFS EYIYKWCSVR VALYRQRSRT ALSKGKDYLV
   661  LAQPPLLLPA ESVDVSVLQP LSGELENTNI EREAETVVLG DLSSSMHQDD LVNHTVDAVE
   721  LEPSHSQTLS QSLLLDITPE INPLPKIEVS ESVEYEAGHI PSPVIPQESS VEIDNETEQK
   781  SESFSSIEKP SITYETNKVN ELMDNIIKED VNSMQIFTKL SETIVPPINT ATVPDNEDGE
   841  AKMNIADTAK QTLISVVDSS SLPEVKEEEQ SPEDALLRGL QRTATDFYAE LQNSTDLGYA
   901  NGNLVHGSNQ KESVFMRLNN RIKALEVNMS LSGRYLEELS QRYRKQMEEM QKAFNKTIVK
   961  LQNTSRIAEE QDQRQTEAIQ LLQAQLTNMT QLVSNLSATV AELKREVSDR QSYLVISLVL
  1021  CVVLGLMLCM QRCRNTSQFD GDYISKLPKS NQYPSPKRCF SSYDDMNLKR RTSFPLMRSK
  1081  SLQLTGKEVD PNDLYIVEPL KFSPEKKKKR CKYKIEKIET IKPEEPLHPI ANGDIKGRKP
  1141  FTNQRDFSNM GEVYHSSYKG PPSEGSSETS SQSEESYFCG ISACTSLCNG QSQKTKTEKR
  1201  ALKRRRSKVQ DQGKLIKTLI QTKSGSLPSL HDIIKGNKEI TVGTFGVTAV SGHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUCO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 79 nTPM
epididymis: 58 nTPM
retina: 33 nTPM
parathyroid gland: 26 nTPM
pancreas: 24 nTPM
seminal vesicle: 23 nTPM

Single-cell type

neutrophil progenitors: 729 nCPM
neutrophils: 359 nCPM
epididymal principal cells: 333 nCPM
ocular epithelial cells: 322 nCPM
erythrocyte progenitors: 277 nCPM
sertoli cells: 226 nCPM

Immune cell

basophil: 6.5 nTPM
eosinophil: 6.4 nTPM
NK-cell: 6 nTPM
naive B-cell: 5.3 nTPM
memory B-cell: 4.5 nTPM
naive CD8 T-cell: 4.4 nTPM

Brain region

white matter: 23 nTPM
midbrain: 22 nTPM
basal ganglia: 22 nTPM
hypothalamus: 21 nTPM
spinal cord: 20 nTPM
choroid plexus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.97
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Galactose-binding-like domain superfamily
SUN domain
Sad1 / UNC-like C-terminal
SUN domain-containing Suco/Slp1-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUCO as an antibody target. Whether an autoantibody or antibody against SUCO could matter depends on whether native SUCO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUCO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUCO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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