Seroatlas · Human Serome Atlas

GUSBP11

Putative inactive beta-glucuronidase protein GUSBP11

Also known as: BGP11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P575
Gene: GUSBP11
Canonical length: 273 aa

OverviewNCBI Gene

No narrative summary is available for GUSBP11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q6P575|GUSBP11
     1  MTAAETGRGK PRLGGGSGLG GSPAAVVWLH VGATGRDAVS PREPVVAAQA AGRPLKLPRR
    61  LLRQPTPGLR GAESGPTVDM PVPSSFNDIG QGWRLRHFVS WLWYEREVTL LERWIQDLCT
   121  RVVLRIGSAH FYAIVWVNGV DTVEHEGGYL PFEADISSLF QVEPLPSHLC ITIAINNTLT
   181  PQPCHQGPSV HDRHLQVGTI LPPLHAPTFP PHPVVFLPGT GYPKGYFVQN TDFDFFSYAG
   241  LLWSLLLYTT PPTYIDDVTV TTGVKRDSGE GFW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUSBP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carbohydrate metabolic process

Molecular functions

hydrolyzing O-glycosyl compounds
hydrolase activity

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUSBP11 as an antibody target. Whether an autoantibody or antibody against GUSBP11 could matter depends on whether native GUSBP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUSBP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUSBP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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