Seroatlas · Human Serome Atlas

NR2C2AP

Nuclear receptor 2C2-associated protein

Also known as: NR2CA_HUMAN, TRA16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WQ0
Gene: NR2C2AP
Ensembl: ENSG00000184162
Chromosome: 19
Canonical length: 139 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q86WQ0|NR2C2AP
     1  MTHSLVCPET VSRVSSVLNR NTRQFGKKHL FDQDEETCWN SDQGPSQWVT LEFPQLIRVS
    61  QLQIQFQGGF SSRRGCLEGS QGTQALHKIV DFYPEDNNSL QTFPIPAAEV DRLKVTFEDA
   121  TDFFGRVVIY HLRVLGEKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR2C2AP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skin: 20 nTPM
ovary: 17 nTPM
esophagus: 16 nTPM
urinary bladder: 15 nTPM
breast: 15 nTPM
pancreas: 15 nTPM

Single-cell type

esophageal basal cells: 58 nCPM
migrating cytotrophoblasts: 48 nCPM
epididymal basal cells: 47 nCPM
oocytes: 46 nCPM
breast secretory cells: 37 nCPM
extravillous trophoblasts: 37 nCPM

Immune cell

memory B-cell: 44 nTPM
naive B-cell: 43 nTPM
naive CD4 T-cell: 42 nTPM
MAIT T-cell: 41 nTPM
memory CD4 T-cell: 41 nTPM
naive CD8 T-cell: 40 nTPM

Brain region

white matter: 8.8 nTPM
spinal cord: 6.5 nTPM
medulla oblongata: 6.4 nTPM
cerebellum: 6.1 nTPM
basal ganglia: 5.9 nTPM
cerebral cortex: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.24
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Galactose-binding-like domain superfamily

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of NR2C2AP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NR2C2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR2C2AP as an antibody target. Whether an autoantibody or antibody against NR2C2AP could matter depends on whether native NR2C2AP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR2C2AP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR2C2AP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...