NTN1

Protein identityUniProt · HPA

UniProt accession

O95631

Gene

NTN1

Ensembl

ENSG00000065320

Chromosome

17

Canonical length

604 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Actin filaments,Cytosol

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>O95631|NTN1
     1  MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF
    61  GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW
   121  QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ
   181  CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD
   241  WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD
   301  SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS
   361  GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT
   421  GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK
   481  GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR
   541  DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK
   601  CKKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

56 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NTN1.

Disease | AllUniProt

Conditions NTN1 is implicated in, by any mechanism.

• Mirror movements 4 (MRMV4) MIM:618264

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 125 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Mirror movements 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

2.27

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior axon guidance
• apoptotic process
• Cdc42 protein signal transduction
• cell-cell adhesion
• chemorepulsion of axon
• glial cell proliferation
• inner ear morphogenesis
• mammary gland duct morphogenesis
• motor neuron migration
• negative regulation of axon extension
• nuclear migration
• positive regulation of axon extension
• positive regulation of cell motility
• positive regulation of glial cell proliferation
• Ras protein signal transduction
• regulation of synapse assembly
• regulation of transcription by RNA polymerase II
• substrate-dependent cell migration, cell extension
• regulation of glial cell migration

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• actin cytoskeleton
• basement membrane
• cytosol
• extracellular region
• glutamatergic synapse
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Netrin domain
• Laminin-type EGF domain
• Laminin, N-terminal
• Galactose-binding-like domain superfamily
• Tissue inhibitor of metalloproteinases-like, OB-fold
• Netrin module, non-TIMP type
• Laminin/Netrin Extracellular Matrix
• Laminin/attractin/netrin-like, EGF domain
• Laminin EGF domain
• Laminin N-terminal (Domain VI)
• UNC-6/NTR/C345C module
• Laminin/attractin EGF domain

KeywordsUniProt

• Apoptosis
• Cytoplasm
• Disulfide bond
• Glycoprotein
• Laminin EGF-like domain
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of NTN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APP
• DCC