Seroatlas · Human Serome Atlas

SSPOP

SCO-spondin

Also known as: SSPO_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2VEC9
Gene: SSPOP
Canonical length: 5150 aa

OverviewNCBI Gene

No narrative summary is available for SSPOP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

5150 residues, UniProt reviewed canonical sequence.

>A2VEC9|SSPOP
     1  MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR LGWRLDLPWS
    61  GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG AHCTEALAKA SPEGHCFAMW
   121  QCQLQAGSAN ASAGSLEECC ARPWGQSWWD GSSQACRSCS SRHLPGSASS PALLQPLAGA
   181  VGQLWSQHQR PSATCASWSG FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP
   241  QPGHCQRVTM GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR
   301  LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN SWRLPGSESG
   361  CLDAVEVAQG CDSPLGLIDA DVEPGHLRAE AQDVCHQLLE GPFGQCHAQV SPAEYHEACL
   421  FAYCAGAMAG SGQEGRQQAV CATFASYVQA CARRHIHIRW RKPGFCERLC PGGQLYSDCV
   481  SLCPPSCEAV GQGEEESCRE ECVSGCECPR GLFWNGTLCV PAAHCPCYYC RQRYVPGDTV
   541  RQLCNPCVCR DGRWHCAQAL CPAECAVGGD GHYLTFDGRS YSFWGGQGCR YSLVQDYVKG
   601  QLLILLEHGA CDAGSCLHAI SVSLEDTHIQ LRDSGAVLVN GQDVGLPWIG AEGLSVRRAS
   661  SAFLLLRWPG AQVLWGLSDP VAYITLDPRH AHQVQGLCGT FTQNQQDDFL TPAGDVETSI
   721  AAFASKFQVA GKGRCPSEDS ALLSPCTTHS QRHAFAEAAC AILHSSVFQE CHRLVDKEPF
   781  YLRCLAAVCG CDPGSDCLCP VLSAYARRCA QEGASPPWRN QTLCPVMCPG GQEYRECAPA
   841  CGQHCGKPED CGELGSCVAG CNCPLGLLWD PEGQCVPPSL CPCQLGARRY APGSATMKEC
   901  NRCICQERGL WNCTARHCPS QAFCPRELVY APGACLLTCD SPSANHSCPA GSTDGCVCPP
   961  GTVLLDERCV PPDLCPCRHS GQWYLPNATI QEDCNVCVCR GRQWHCTGQR RSGRCQASGA
  1021  PHYVTFDGLA FTYPGACEYL LVREASGLFT VSAQNLPCGA SGLTCTKALA VRLEGTVVHM
  1081  LRGRAVTVNG VSVTPPKVYT GPGLSLRRAG LFLLLSTHLG LTLLWDGGTR VLVQLSPQFR
  1141  GRVAGLCGDF DGDASNDLRS RQGVLEPTAE LAAHSWRLSP LCPEPGDLPH PCTMNTHRAG
  1201  WARARCGALL QPLFTLCHAE VPPQQHYEWC LYDACGCDSG GDCECLCSAI ATYADECARH
  1261  GHHVRWRSQE LCSLQCEGGQ VYEACGPTCP PTCHEQHPEP GWHCQVVACV EGCFCPEGTL
  1321  LHGGACLEPA SCPCEWGRNS FPPGSVLQKD CGNCTCQEGQ WHCGGDGGHC EELVPACAEG
  1381  EALCQENGHC VPHGWLCDNQ DDCGDGSDEE GCAAPGCGEG QMTCSSGHCL PLALLCDRQD
  1441  DCGDGTDEPS YPCPQGLLAC ADGRCLPPAL LCDGHPDCLD AADEESCLGQ VTCVPGEVSC
  1501  VDGTCLGAIQ LCDGVWDCPD GADEGPGHCP LPSLPTPPAS TLPGPSPGSL DTASSPLASA
  1561  SPAPPCGPFE FRCGSGECTP RGWRCDQEED CADGSDERGC GGPCAPHHAP CARGPHCVSP
  1621  EQLCDGVRQC PDGSDEGPDA CGGLPALGGP NRTGLPCPEY TCPNGTCIGF QLVCDGQPDC
  1681  GRPGQVGPSP EEQGCGAWGP WSPWGPCSRT CGPWGQGRSR RCSPLGLLVL QNCPGPEHQS
  1741  QACFTAACPV DGEWSTWSPW SVCSEPCRGT MTRQRQCHSP QNGGRTCAAL PGGLHSTRQT
  1801  KPCPQDGCPN ATCSGELMFQ PCAPCPLTCD DISGQVTCPP DWPCGSPGCW CPEGQVLGSE
  1861  GWCVWPRQCP CLVDGARYWP GQRIKADCQL CICQDGRPRR CRLNPDCAVD CGWSSWSPWA
  1921  KCLGPCGSQS IQWSFRSSNN PRPSGRGRQC RGIHRKARRC QTEPCEGCEH QGQVHRVGER
  1981  WHGGPCRVCQ CLHNLTAHCS PYCPLGSCPQ GWVLVEGTGE SCCHCALPGE NQTVQPMATP
  2041  AAAPAPSPQI RFPLATYILP PSGDPCYSPL GLAGLAEGSL HASSQQLEHP TQAALLGAPT
  2101  QGPSPQGWHA GGDAYAKWHT RPHYLQLDLL QPRNLTGILV PETGSSNAYA SSFSLQFSSN
  2161  GLHWHDYRDL LPGILPLPKL FPRNWDDLDP AVWTFGRMVQ ARFVRVWPHD VHHSDVPLQV
  2221  ELLGCEPGSP PAPLCPGVGL RCASGECVLR GGPCDGVLDC EDGSDEEGCV LLPEGTGRFH
  2281  STAKTLALSS AQPGQLLHWP REGLAETEHW PPGQESPTSP TETRPVSPGP ASGVPHHGES
  2341  VQMVTTTPIP QMEARTLPPG MAAVTVVPPH PVTPATPAGQ SVAPGPFPPV QCGPGQTPCE
  2401  VLGCVEQAQV CDGREDCLDG SDERHCARNL LMWLPSLPAL WAASTVPFMM PTMALPGLPA
  2461  SRALCSPSQL SCGSGECLSA ERRCDLRPDC QDGSDEDGCV DCVLAPWSVW SSCSRSCGLG
  2521  LTFQRQELLR PPLPGGSCPR DRFRSQSCFV QACPVAGAWA MWEAWGPCSV SCGGGHQSRQ
  2581  RSCVDPPPKN GGAPCPGASQ ERAPCGLQPC SGGTDCELGR VYVSADLCQK GLVPPCPPSC
  2641  LDPKANRSCS GHCVEGCRCP PGLLLHDTRC LPLSECPCLV GEELKWPGVS FLLGNCSQCV
  2701  CEKGELLCQP GGCPLPCGWS AWSSWAPCDR SCGSGVRARF RSPSNPPAAW GGAPCEGDRQ
  2761  ELQGCHTVCG TEVFGWTPWT SWSSCSQSCL APGGGPGWRS RSRLCPSPGD SSCPGDATQE
  2821  EPCSPPVCPV PSIWGLWAPW STCSAPCDGG IQTRGRSCSS LAPGDTTCPG PHSQTRDCNT
  2881  QPCTAQCPEN MLFRSAEQCH QEGGPCPRLC LTQGPGIECT GFCAPGCTCP PGLFLHNASC
  2941  LPRSQCPCQL HGQLYASGAM ARLDSCNNCT CVSGKMACTS ERCPVACGWS PWTLWSLCSC
  3001  SCNVGIRRRF RAGTAPPAAF GGAECQGPTM EAEFCSLRPC PGPGGEWGPW SPCSVPCGGG
  3061  YRNRTRGSSR SLMEFSTCGL QPCAGPVPGM CPRDKQWLDC AQGPASCAEL SAPRGTNQTC
  3121  HPGCHCPSGM LLLNNVCVPT QDCPCAHEGH LYPPGSTVVR PCENCSCVSG LIANCSSWPC
  3181  AEGEPTWSPW TPWSQCSASC GPARCHRHRF CARSPSAVPS TVAPLPLPAT PTPLCSGPEA
  3241  EEEPCLLQGC DRAGGWGPWG PWSHCSRSCG GGLRSRTRAC DQPPPQGLGD YCEGPRAQGE
  3301  VCQALPCPVT NCTAIEGAEY SPCGPPCPRS CDDLVHCVWR CQPGCYCPPG QVLSSNGAIC
  3361  VQPGHCSCLD LLTGQRHHPG ARLARPDGCN HCTCLEGRLN CTDLPCPVPG GWCPWSEWTM
  3421  CSQPCRGQTR SRSRACACPT PQHGGAPCTG EAGEAGAQHQ REACPSYATC PVDGAWGPWG
  3481  PWSPCDMCLG QSHRSRACSR PPTPEGGRPC PGNHTQSRPC QENSTQCTDC GGGQSLHPCG
  3541  QPCPRSCQDL SPGSVCQPGS VGCQPTCGCP LGQLSQDGLC VPPAHCRCQY QPGAMGIPEN
  3601  QSRSAGSRFS SWESLEPGEV VTGPCDNCTC VAGILQCQEV PDCPDPGVWS SWGPWEDCSV
  3661  SCGGGEQLRS RRCARPPCPG PARQSRTCST QVCREAGCPA GRLYRECQPG EGCPFSCAHV
  3721  TQQVGCFSEG CEEGCHCPEG TFQHRLACVQ ECPCVLTAWL LQELGATIGD PGQPLGPGDE
  3781  LDSGQTLRTS CGNCSCAHGK LSCSLDDCFE ADGGFGPWSP WGPCSRSCGG LGTRTRSRQC
  3841  VLTMPTLSGQ GCRGPRQDLE YCPSPDCPGA EGSTVEPVTG LPGGWGPWSS WSPCSRSCTD
  3901  PARPAWRSRT RLCLANCTMG DPLQERPCNL PSCTELPVCP GPGCGAGNCS WTSWAPWEPC
  3961  SRSCGVGQQR RLRAYRPPGP GGHWCPNILT AYQERRFCNL RACPVPGGWS RWSPWSWCDR
  4021  SCGGGQSLRS RSCSSPPSKN GGAPCAGERH QARLCNPMPC EAGCPAGMEV VTCANRCPRR
  4081  CSDLQEGIVC QDDQVCQKGC RCPKGSLEQD GGCVPIGHCD CTDAQGHSWA PGSQHQDACN
  4141  NCSCQAGQLS CTAQPCPPPT HCAWSHWSAW SPCSHSCGPR GQQSRFRSST SGSWAPECRE
  4201  EQSQSQPCPQ PSCPPLCLQG TRSRTLGDSW LQGECQRCSC TPEGVICEDT ECAVPEAWTL
  4261  WSSWSDCPVS CGGGNQVRTR ACRAAAPHHR SPPCLGPDTQ TRQQPCPGLL EACSWGPWGP
  4321  CSRSCGPGLA SRSGSCPCLM AKADPTCNST FLHLDTQGCY SGPCPEECVW SSWSSWTRCS
  4381  CRVLVQQRYR HQGPASRGAR AGAPCTRLDG HFRPCLISNC SEDSCTPPFE FHACGSPCAG
  4441  LCATHLSHQL CQDLPPCQPG CYCPKGLLEQ AGGCIPPEEC NCWHTSAAGA GMTLAPGDRL
  4501  QLGCKECECR RGELHCTSQG CQGLLPLSEW SEWSPCGPCL PPSALAPASR TALEEHWLRD
  4561  PTGLSPTLAP LLASEQHRHR LCLDPATGRP WTGAPHLCTA PLSQQRLCPD PGACPDSCQW
  4621  SLWGPWSPCQ VPCSGGFRLR WREAEALCGG GCREPWAQES CNGGPCPESC EAQDTVFTLD
  4681  CANQCPHSCA DLWDRVQCLQ GPCRPGCRCP PGQLVQDGRC VPISSCRCGL PSANASWELA
  4741  PAQAVQLDCQ NCTCVNESLV CPHQECPVLG PWSAWSSCSA PCGGGTMERH RTCEGGPGVA
  4801  PCQAQDTEQR QECNLQPCPE CPPGQVLSAC ATSCPCLCWH LQPGAICVQE PCQPGCGCPG
  4861  GQLLHNGTCV PPTACPCTQH SLPWGLTLTL EEQAQELPPG TVLTRNCTRC VCHGGAFSCS
  4921  LVDCQVPPGE TWQQVAPGEL GLCEQTCLEM NATKTQSNCS SARASGCVCQ PGHFRSQAGP
  4981  CVPEDHCECW HLGRPHLPGS EWQEACESCL CLSGRPVCTQ HCSPLTCAQG EEMVLEPGSC
  5041  CPSCRREAPE EQSPSCQLLT ELRNFTKGTC YLDQVEVSYC SGYCPSSTHV MPEEPYLQSQ
  5101  CDCCSYRLDP ESPVRILNLR CLGGHTEPVV LPVIHSCQCS SCQGGDFSKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSPOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SSPOP.

Disease | ImmuneIEDB

Conditions an epitope on SSPOP was assayed in.

rheumatoid arthritis B cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSPOP as an antibody target. Whether an autoantibody or antibody against SSPOP could matter depends on whether native SSPOP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSPOP is annotated as secreted, so native SSPOP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SSPOP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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