Seroatlas · Human Serome Atlas

ANAPC10

Anaphase-promoting complex subunit 10

Also known as: APC10, APC10_HUMAN, DKFZP564L0562, DOC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UM13
Gene
ANAPC10
Ensembl
ENSG00000164162
Chromosome
4
Canonical length
185 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q9UM13|ANAPC10
     1  MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ
    61  PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI
   121  HVPLTDNHKK PTRTFMIQIA VLANHQNGRD THMRQIKIYT PVEESSIGKF PRCTTIDFMM
   181  YRSIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • skeletal muscle: 14 nTPM
  • tongue: 14 nTPM
  • breast: 13 nTPM
  • heart muscle: 13 nTPM
  • thymus: 13 nTPM

Single-cell type

  • distal convoluted tubule cells: 106 nCPM
  • podocytes: 88 nCPM
  • renal connecting tubule cells: 79 nCPM
  • renal collecting duct intercalated cells: 79 nCPM
  • proximal tubule cells: 74 nCPM
  • loop of henle epithelial cells: 69 nCPM

Immune cell

  • basophil: 26 nTPM
  • T-reg: 18 nTPM
  • NK-cell: 17 nTPM
  • plasmacytoid DC: 16 nTPM
  • memory B-cell: 15 nTPM
  • naive CD8 T-cell: 14 nTPM

Brain region

  • cerebellum: 9.5 nTPM
  • white matter: 8.2 nTPM
  • midbrain: 8.1 nTPM
  • spinal cord: 7.5 nTPM
  • hypothalamus: 7.4 nTPM
  • medulla oblongata: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.01
gnomAD missense Z
0.84
DepMap mean gene effect
-1.65
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC10 as an antibody target. Whether an autoantibody or antibody against ANAPC10 could matter depends on whether native ANAPC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANAPC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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