Seroatlas · Human Serome Atlas

CNTNAP4

Contactin-associated protein-like 4

Also known as: CASPR4, CNTP4_HUMAN, KIAA1763

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0A0
Gene
CNTNAP4
Ensembl
ENSG00000152910
Chromosome
16
Canonical length
1308 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the neurexin protein family. Members of this family function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. This protein may also play a role in proper neurotransmission in the dopaminergic and GABAergic systems and mutations in this gene may be associated with certain psychiatric illnesses. A polymorphism in an intron of this gene may be associated with longevity. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

1308 residues, UniProt reviewed canonical sequence.

>Q9C0A0|CNTNAP4
     1  MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL SSSHGPGFAR
    61  LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY GSSNWVTSYL LMFSDSGWNW
   121  KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR
   181  SEVVDLDGKS SLLYRFDQKS LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR
   241  LFLLINSGEA KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
   301  FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ KPQIIAMGNV
   361  SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT WNKAGLLLFS ELQLISGGIL
   421  LFLSDGKLKS NLYQPGKLPS DITAGVELND GQWHSVSLSA KKNHLSVAVD GQMASAAPLL
   481  GPEQIYSGGT YYFGGCPDKS FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS
   541  DLQIDSCGIS DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR
   601  GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE NPYAGFFEYV
   661  ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW WVGRTNETQT YWGGSSPDLQ
   721  KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT GLLAYKEHLP VTKIVITDTG RLHSEAAYKL
   781  GPLLCQGDRS FWNSASFDTE ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI
   841  RIELRSPTVV TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ
   901  PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV TPEVQPGCRG
   961  HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI SAYFGSGSSV IYNFQENYLL
  1021  SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR TPSLLLFVSS FYKEYLSVII AKNGSLQIRY
  1081  KLNKYQEPDV VNFDFKNMAD GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS
  1141  LVLGRILEHS DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES
  1201  SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV IFILLCITAI
  1261  AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN ENQKEYFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNTNAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 95 nTPM
  • midbrain: 37 nTPM
  • hippocampal formation: 22 nTPM
  • cerebral cortex: 21 nTPM
  • hypothalamus: 19 nTPM
  • cerebellum: 16 nTPM

Single-cell type

  • early spermatids: 8.4 nCPM
  • late primary spermatocytes: 3.5 nCPM
  • late spermatids: 2.7 nCPM
  • distal convoluted tubule cells: 2.2 nCPM
  • renal collecting duct principal cells: 1.9 nCPM
  • renal connecting tubule cells: 1.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 245 nTPM
  • medulla oblongata: 160 nTPM
  • pons: 124 nTPM
  • basal ganglia: 119 nTPM
  • thalamus: 111 nTPM
  • cerebral cortex: 100 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
-1.24
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNTNAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNTNAP4 as an antibody target. Whether an autoantibody or antibody against CNTNAP4 could matter depends on whether native CNTNAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNTNAP4 is annotated at the cell surface, where native CNTNAP4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNTNAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNTNAP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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