DDR2

Protein identityUniProt · HPA

UniProt accession

Q16832

Gene

DDR2

Ensembl

ENSG00000162733

Chromosome

1

Canonical length

855 aa

Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane,Actin filaments

OverviewNCBI Gene

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>Q16832|DDR2
     1  MILIPRMLLV LFLLLPILSS AKAQVNPAIC RYPLGMSGGQ IPDEDITASS QWSESTAAKY
    61  GRLDSEEGDG AWCPEIPVEP DDLKEFLQID LHTLHFITLV GTQGRHAGGH GIEFAPMYKI
   121  NYSRDGTRWI SWRNRHGKQV LDGNSNPYDI FLKDLEPPIV ARFVRFIPVT DHSMNVCMRV
   181  ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD
   241  DFTQTHEYHV WPGYDYVGWR NESATNGYIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK
   301  EVQCYFRSEA SEWEPNAISF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS
   361  EITFQSDAAM YNNSEALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL
   421  WRQFWQKMLE KASRRMLDDE MTVSLSLPSD SSMFNNNRSS SPSEQGSNST YDRIFPLRPD
   481  YQEPSRLIRK LPEFAPGEEE SGCSGVVKPV QPSGPEGVPH YAEADIVNLQ GVTGGNTYSV
   541  PAVTMDLLSG KDVAVEEFPR KLLTFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN
   601  QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIHL LAVCITDDPL CMITEYMENG
   661  DLNQFLSRHE PPNSSSSDVR TVSYTNLKFM ATQIASGMKY LSSLNFVHRD LATRNCLVGK
   721  NYTIKIADFG MSRNLYSGDY YRIQGRAVLP IRWMSWESIL LGKFTTASDV WAFGVTLWET
   781  FTFCQEQPYS QLSDEQVIEN TGEFFRDQGR QTYLPQPAIC PDSVYKLMLS CWRRDTKNRP
   841  SFQEIHLLLL QQGDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

56 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDR2.

Disease | AllUniProt

Conditions DDR2 is implicated in, by any mechanism.

• Spondyloepimetaphyseal dysplasia, short limb-hand type (SEMD-SL) MIM:271665
• Warburg-Cinotti syndrome (WRCN) MIM:618175

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 481 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome
• Warburg-cinotti syndrome
• Ovarian serous cystadenocarcinoma
• Fetal growth restriction

Disease | ImmuneIEDB

Conditions an epitope on DDR2 was assayed in.

• lung non-small cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.55

gnomAD missense Z

2.29

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• biomineral tissue development
• cell adhesion
• cell surface receptor protein tyrosine kinase signaling pathway
• cellular response to angiotensin
• cellular response to hypoxia
• cellular response to transforming growth factor beta stimulus
• chondrocyte proliferation
• collagen fibril organization
• collagen-activated tyrosine kinase receptor signaling pathway
• endochondral bone growth
• negative regulation of apoptotic process
• negative regulation of hydrogen peroxide-mediated programmed cell death
• ossification
• peptidyl-tyrosine phosphorylation
• positive regulation of collagen biosynthetic process
• positive regulation of DNA-binding transcription factor activity
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of extracellular matrix disassembly
• positive regulation of fibroblast migration
• positive regulation of fibroblast proliferation
• positive regulation of G1/S transition of mitotic cell cycle
• positive regulation of hepatic stellate cell activation
• positive regulation of hepatic stellate cell proliferation
• positive regulation of neuron projection development
• positive regulation of osteoblast differentiation
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of protein kinase activity
• positive regulation of vascular associated smooth muscle cell migration
• positive regulation of vascular associated smooth muscle cell proliferation
• positive regulation of wound healing
• protein autophosphorylation
• regulation of bone mineralization
• regulation of extracellular matrix disassembly
• regulation of tissue remodeling
• response to muscle stretch
• signal transduction

Molecular functions

• ATP binding
• collagen binding
• protein tyrosine kinase collagen receptor activity
• transmembrane receptor protein tyrosine kinase activity

Cellular components

• actin cytoskeleton
• apical plasma membrane
• focal adhesion
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Coagulation factor 5/8, C-terminal domain
• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase, receptor class II, conserved site
• Tyrosine-protein kinase, active site
• Galactose-binding-like domain superfamily
• Protein kinase-like domain superfamily
• Tyrosine-protein kinase, catalytic domain
• Discoidin domain-containing receptor 1/2, DS-like domain
• Receptor Tyrosine Kinase
• F5/8 type C domain
• Protein tyrosine and serine/threonine kinase
• Discoidin domain-containing receptor 1/2, DS-like domain

KeywordsUniProt

• ATP-binding
• Cell membrane
• Disulfide bond
• Dwarfism
• Glycoprotein
• Kinase
• Membrane
• Nucleotide-binding
• Osteogenesis
• Phosphoprotein
• Receptor
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of DDR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SRC
• SHC1
• CDC37
• DDR1
• HSP90AB1
• NTRK3