Seroatlas · Human Serome Atlas

FBXO6

F-box only protein 6

Also known as: FBG2, FBS2, FBX6, FBX6_HUMAN, Fbx6b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRD1
Gene
FBXO6
Ensembl
ENSG00000116663
Chromosome
1
Canonical length
293 aa
Protein class
Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q9NRD1|FBXO6
     1  MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL MTLWKRKCLR
    61  EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA WQIDFNGGDR WKVESLPGAH
   121  GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA EGYWEELLDT FRPDIVVKDW FAARADCGCT
   181  YQLKVQLASA DYFVLASFEP PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ
   241  YWAGWYGPRV TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • liver: 19 nTPM
  • skeletal muscle: 19 nTPM
  • bone marrow: 18 nTPM
  • lymph node: 17 nTPM
  • pancreas: 14 nTPM
  • tongue: 14 nTPM

Single-cell type

  • late spermatids: 190 nCPM
  • early spermatids: 77 nCPM
  • oocytes: 37 nCPM
  • fallopian tube ciliated cells: 35 nCPM
  • esophageal suprabasal cells: 31 nCPM
  • respiratory ciliated cells: 30 nCPM

Immune cell

  • non-classical monocyte: 91 nTPM
  • intermediate monocyte: 75 nTPM
  • myeloid DC: 66 nTPM
  • eosinophil: 65 nTPM
  • classical monocyte: 49 nTPM
  • gdT-cell: 47 nTPM

Brain region

  • hypothalamus: 14 nTPM
  • midbrain: 11 nTPM
  • thalamus: 9.8 nTPM
  • spinal cord: 9.5 nTPM
  • basal ganglia: 8.9 nTPM
  • pons: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.02
gnomAD missense Z
-0.25
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO6 as an antibody target. Whether an autoantibody or antibody against FBXO6 could matter depends on whether native FBXO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXO6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...