Seroatlas · Human Serome Atlas

CPXM1

Probable carboxypeptidase X1

Also known as: CPX-1, CPX1, CPXM, CPXM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SM3
Gene: CPXM1
Ensembl: ENSG00000088882
Chromosome: 20
Canonical length: 734 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

734 residues, UniProt reviewed canonical sequence.

>Q96SM3|CPXM1
     1  MWGLLLALAA FAPAVGPALG APRNSVLGLA QPGTTKVPGS TPALHSSPAQ PPAETANGTS
    61  EQHVRIRVIK KKKVIMKKRK KLTLTRPTPL VTAGPLVTPT PAGTLDPAEK QETGCPPLGL
   121  ESLRVSDSRL EASSSQSFGL GPHRGRLNIQ SGLEDGDLYD GAWCAEEQDA DPWFQVDAGH
   181  PTRFSGVITQ GRNSVWRYDW VTSYKVQFSN DSRTWWGSRN HSSGMDAVFP ANSDPETPVL
   241  NLLPEPQVAR FIRLLPQTWL QGGAPCLRAE ILACPVSDPN DLFLEAPASG SSDPLDFQHH
   301  NYKAMRKLMK QVQEQCPNIT RIYSIGKSYQ GLKLYVMEMS DKPGEHELGE PEVRYVAGMH
   361  GNEALGRELL LLLMQFLCHE FLRGNPRVTR LLSEMRIHLL PSMNPDGYEI AYHRGSELVG
   421  WAEGRWNNQS IDLNHNFADL NTPLWEAQDD GKVPHIVPNH HLPLPTYYTL PNATVAPETR
   481  AVIKWMKRIP FVLSANLHGG ELVVSYPFDM TRTPWAAREL TPTPDDAVFR WLSTVYAGSN
   541  LAMQDTSRRP CHSQDFSVHG NIINGADWHT VPGSMNDFSY LHTNCFEVTV ELSCDKFPHE
   601  NELPQEWENN KDALLTYLEQ VRMGIAGVVR DKDTELGIAD AVIAVDGINH DVTTAWGGDY
   661  WRLLTPGDYM VTASAEGYHS VTRNCRVTFE EGPFPCNFVL TKTPKQRLRE LLAAGAKVPP
   721  DLRRRLERLR GQKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPXM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

ovary: 107 nTPM
gallbladder: 81 nTPM
endometrium: 72 nTPM
adipose tissue: 56 nTPM
cervix: 55 nTPM
urinary bladder: 52 nTPM

Single-cell type

decidual stromal cells: 692 nCPM
endometrial stromal cells: 123 nCPM
megakaryocyte progenitors: 43 nCPM
fibroblasts: 36 nCPM
mesothelial cells: 35 nCPM
ovarian stromal cells: 34 nCPM

Immune cell

NK-cell: 1.3 nTPM
memory B-cell: 0.6 nTPM
myeloid DC: 0.4 nTPM
plasmacytoid DC: 0.3 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 4.5 nTPM
choroid plexus: 4 nTPM
thalamus: 2 nTPM
basal ganglia: 1.3 nTPM
pons: 1.2 nTPM
spinal cord: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPXM1 as an antibody target. Whether an autoantibody or antibody against CPXM1 could matter depends on whether native CPXM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPXM1 is annotated as secreted, so native CPXM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CPXM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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