Seroatlas · Human Serome Atlas

PCSK5

Proprotein convertase subtilisin/kexin type 5

Also known as: PC5, PC6, PCSK5_HUMAN, SPC6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92824
Gene
PCSK5
Ensembl
ENSG00000099139
Chromosome
9
Canonical length
1860 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

1860 residues, UniProt reviewed canonical sequence.

>Q92824|PCSK5
     1  MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA NRIASKYGFI
    61  NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR
   121  AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD
   181  LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG
   241  GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
   301  RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS
   361  SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR
   421  AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVMEAEKWT TVPRQHVCVE STDRQIKTIR
   481  PNSAVRSIYK ASGCSDNPNR HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR
   541  LFDHSMEGFK NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
   601  QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP DHCNDCLHYY
   661  YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH GDQCMSCKYG YFLNEETNSC
   721  VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ
   781  DCQPCHRFCA TCAGAGADGC INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI
   841  SCLTCNGPGF KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ
   901  EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC TSCGADNYGR
   961  EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV CTRCMKGYFI APTNHTCQKL
  1021  ECGQGEVQDP DYEECVPCEE GCLGCSLDDP GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV
  1081  ECKACDSNCG SCDQNGCYWC EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG
  1141  PGHDECSSCQ EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC
  1201  PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ PGHPLFLHEG
  1261  RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG HVLHHGVCQE NCPERHVAVK
  1321  GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD DMCHQSCPRG FYADSRHCVP CHKDCLECSG
  1381  PKADDCELCL ESSWVLYDGL CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG
  1441  LIMNPRGSCM ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC
  1501  VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL LQCREGYYAD
  1561  NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC HRSCPDHYYV EQSTQTCERC
  1621  HPTCDQCKGK GALNCLSCVW SYHLMGGICT SDCLVGEYRV GEGEKFNCEK CHESCMECKG
  1681  PGAKNCTLCP ANLVLHMDDS HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH
  1741  FKTALFITSS MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST
  1801  SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE YDDESYSYYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCSK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 24 nTPM
  • duodenum: 23 nTPM
  • adipose tissue: 15 nTPM
  • ovary: 12 nTPM
  • blood vessel: 12 nTPM
  • colon: 9 nTPM

Single-cell type

  • enterocytes: 1,868 nCPM
  • esophageal apical cells: 793 nCPM
  • bergmann glia: 701 nCPM
  • retinal horizontal cells: 675 nCPM
  • ocular epithelial cells: 659 nCPM
  • colonocytes: 578 nCPM

Immune cell

  • naive CD8 T-cell: 4.9 nTPM
  • gdT-cell: 2.6 nTPM
  • total PBMC: 2.1 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • NK-cell: 1.6 nTPM
  • memory CD8 T-cell: 1.3 nTPM

Brain region

  • cerebral cortex: 9 nTPM
  • hypothalamus: 8.3 nTPM
  • basal ganglia: 7.6 nTPM
  • hippocampal formation: 6.8 nTPM
  • pons: 6.7 nTPM
  • medulla oblongata: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0
gnomAD missense Z
2.57
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCSK5 as an antibody target. Whether an autoantibody or antibody against PCSK5 could matter depends on whether native PCSK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCSK5 is annotated as secreted, so native PCSK5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PCSK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCSK5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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