Seroatlas · Human Serome Atlas

GLB1L3

Beta-galactosidase-1-like protein 3

Also known as: FLJ90231, GLBL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCI6
Gene: GLB1L3
Ensembl: ENSG00000166105
Chromosome: 11
Canonical length: 653 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>Q8NCI6|GLB1L3
     1  MKSPPLLSPC LSWKRMAGIF FLPFISSGFA PRFKQEENFM LGRAHPSQPR FNWSHLTPLE
    61  LKNRSVGLGT ESTGRGKPHF TLEGHKFLIF GGSIHYFRVP REYWRDRLLK LKACGFNTVT
   121  TYVPWNLHEP ERGKFDFSGN LDLEAFVLMA AEIGLWVILR PGRYICSEMD LGGLPSWLLQ
   181  DPRLLLRTTN KSFIEAVEKY FDHLIPRVIP LQYRQAGPVI AVQVENEYGS FNKDKTYMPY
   241  LHKALLRRGI VELLLTSDGE KHVLSGHTKG VLAAINLQKL HQDTFNQLHK VQRDKPLLIM
   301  EYWVGWFDRW GDKHHVKDAK EVEHAVSEFI KYEISFNVYM FHGGTNFGFM NGATYFGKHS
   361  GIVTSYDYDA VLTEAGDYTE KYLKLQKLFQ SVSATPLPRV PKLPPKAVYP PVRPSLYLPL
   421  WDALSYLNEP VRSRQPVNME NLPINNGSGQ SYGLVLYEKS ICSGGRLRAH AHDVAQVFLD
   481  ETMIGILNEN NKDLHIPELR DCRYLRILVE NQGRVNFSWQ IQNEQKGITG SVSINNSSLE
   541  GFTIYSLEMK MSFFERLRSA TWKPVPDSHQ GPAFYCGTLK AGPSPKDTFL SLLNWNYGFV
   601  FINGRNLGRY WNIGPQKTLY LPGVWLHPED NEVILFEKMM SGSDIKSTDK PTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLB1L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

prostate: 7.5 nTPM
seminal vesicle: 4.1 nTPM
cerebellum: 2.7 nTPM
cerebral cortex: 2.2 nTPM
skin: 2.2 nTPM
salivary gland: 1.9 nTPM

Single-cell type

brain excitatory neurons: 34 nCPM
retinal ganglion cells: 31 nCPM
brain inhibitory neurons: 30 nCPM
undifferentiated spermatogonia: 25 nCPM
other brain neurons: 22 nCPM
differentiating spermatogonia: 21 nCPM

Immune cell

memory CD4 T-cell: 3.1 nTPM
naive CD4 T-cell: 2.4 nTPM
memory CD8 T-cell: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM
T-reg: 1.5 nTPM
gdT-cell: 1.2 nTPM

Brain region

cerebral cortex: 17 nTPM
cerebellum: 12 nTPM
white matter: 9.5 nTPM
basal ganglia: 9.1 nTPM
pons: 8.3 nTPM
hippocampal formation: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLB1L3 as an antibody target. Whether an autoantibody or antibody against GLB1L3 could matter depends on whether native GLB1L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLB1L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLB1L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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