DCBLD1
Discoidin, CUB and LCCL domain-containing protein 1
Also known as: DCBD1_HUMAN, dJ94G16.1, MGC46341
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8Z6
- Gene
- DCBLD1
- Ensembl
- ENSG00000164465
- Chromosome
- 6
- Canonical length
- 715 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable signaling receptor activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
715 residues, UniProt reviewed canonical sequence.
>Q8N8Z6|DCBLD1
1 MVPGARGGGA LARAAGRGLL ALLLAVSAPL RLQAEELGDG CGHLVTYQDS GTMTSKNYPG
61 TYPNHTVCEK TITVPKGKRL ILRLGDLDIE SQTCASDYLL FTSSSDQYGP YCGSMTVPKE
121 LLLNTSEVTV RFESGSHISG RGFLLTYASS DHPDLITCLE RASHYLKTEY SKFCPAGCRD
181 VAGDISGNMV DGYRDTSLLC KAAIHAGIIA DELGGQISVL QRKGISRYEG ILANGVLSRD
241 GSLSDKRFLF TSNGCSRSLS FEPDGQIRAS SSWQSVNESG DQVHWSPGQA RLQDQGPSWA
301 SGDSSNNHKP REWLEIDLGE KKKITGIRTT GSTQSNFNFY VKSFVMNFKN NNSKWKTYKG
361 IVNNEEKVFQ GNSNFRDPVQ NNFIPPIVAR YVRVVPQTWH QRIALKVELI GCQITQGNDS
421 LVWRKTSQST SVSTKKEDET ITRPIPSEET STGINITTVA IPLVLLVVLV FAGMGIFAAF
481 RKKKKKGSPY GSAEAQKTDC WKQIKYPFAR HQSAEFTISY DNEKEMTQKL DLITSDMADY
541 QQPLMIGTGT VTRKGSTFRP MDTDAEEAGV STDAGGHYDC PQRAGRHEYA LPLAPPEPEY
601 ATPIVERHVL RAHTFSAQSG YRVPGPQPGH KHSLSSGGFS PVAGVGAQDG DYQRPHSAQP
661 ADRGYDRPKA VSALATESGH PDSQKPPTHP GTSDSYSAPR DCLTPLNQTA MTALLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DCBLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 9.4 nTPM
Expression across tissuesHPA
Tissue
- lung: 9.4 nTPM
- liver: 9 nTPM
- gallbladder: 8.5 nTPM
- placenta: 8.2 nTPM
- adipose tissue: 7.9 nTPM
- pituitary gland: 7.9 nTPM
Single-cell type
- pericytes: 121 nCPM
- gonadotrophs: 79 nCPM
- cardiomyocytes: 69 nCPM
- corticotrophs: 61 nCPM
- cytotrophoblasts: 51 nCPM
- alveolar cells type 2: 50 nCPM
Immune cell
- naive CD8 T-cell: 1.3 nTPM
- memory CD8 T-cell: 1.2 nTPM
- naive CD4 T-cell: 1 nTPM
- T-reg: 0.9 nTPM
- memory CD4 T-cell: 0.8 nTPM
- gdT-cell: 0.6 nTPM
Brain region
- cerebral cortex: 8.8 nTPM
- basal ganglia: 6.9 nTPM
- white matter: 6.2 nTPM
- pons: 5.1 nTPM
- midbrain: 4.9 nTPM
- amygdala: 4.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.79
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.62
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DCBLD1 as an antibody target. Whether an autoantibody or antibody against DCBLD1 could matter depends on whether native DCBLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DCBLD1 is annotated at the cell surface, where native DCBLD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label DCBLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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