Seroatlas · Human Serome Atlas

FBXO27

F-box only protein 27

Also known as: Fbg5, Fbx27, FBX27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI29
Gene: FBXO27
Ensembl: ENSG00000161243
Chromosome: 19
Canonical length: 283 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q8NI29|FBXO27
     1  MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC RQVCRGWRAL
    61  VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP LGRFCARRPI GRNLIRNPCG
   121  QEGLRKWMVQ HGGDGWVVEE NRTTVPGAPS QTCFVTSFSW CCKKQVLDLE EEGLWPELLD
   181  SGRIEICVSD WWGARHDSGC MYRLLVQLLD ANQTVLDKFS AVPDPIPQWN NNACLHVTHV
   241  FSNIKMGVRF VSFEHRGQDT QFWAGHYGAR VTNSSVIVRV RLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

skin: 35 nTPM
cerebellum: 20 nTPM
heart muscle: 18 nTPM
cerebral cortex: 16 nTPM
esophagus: 15 nTPM
amygdala: 14 nTPM

Single-cell type

cytotrophoblasts: 77 nCPM
retinal amacrine cells: 46 nCPM
ocular epithelial cells: 44 nCPM
syncytiotrophoblasts: 44 nCPM
brain excitatory neurons: 36 nCPM
esophageal suprabasal cells: 32 nCPM

Immune cell

NK-cell: 1.7 nTPM
neutrophil: 1.5 nTPM
basophil: 1 nTPM
naive B-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
gdT-cell: 0.3 nTPM

Brain region

cerebellum: 83 nTPM
cerebral cortex: 69 nTPM
amygdala: 68 nTPM
white matter: 59 nTPM
basal ganglia: 58 nTPM
hippocampal formation: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO27 as an antibody target. Whether an autoantibody or antibody against FBXO27 could matter depends on whether native FBXO27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...