Seroatlas · Human Serome Atlas

XRCC1

DNA repair protein XRCC1

Also known as: RCC, XRCC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18887
Gene
XRCC1
Ensembl
ENSG00000073050
Chromosome
19
Canonical length
633 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>P18887|XRCC1
     1  MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI
    61  GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA
   121  AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE
   181  SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE
   241  SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR
   301  GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL
   361  ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR YLMAGPGSSS EEDEASHSGG
   421  SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN
   481  GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP
   541  DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD
   601  NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XRCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 34 nTPM
  • pituitary gland: 33 nTPM
  • thymus: 27 nTPM
  • cervix: 25 nTPM
  • testis: 25 nTPM
  • blood vessel: 24 nTPM

Single-cell type

  • oocytes: 55 nCPM
  • megakaryocytes: 50 nCPM
  • respiratory ciliated cells: 46 nCPM
  • cytotrophoblasts: 37 nCPM
  • late primary spermatocytes: 36 nCPM
  • migrating cytotrophoblasts: 32 nCPM

Immune cell

  • basophil: 19 nTPM
  • eosinophil: 16 nTPM
  • neutrophil: 15 nTPM
  • memory CD8 T-cell: 15 nTPM
  • T-reg: 15 nTPM
  • memory CD4 T-cell: 14 nTPM

Brain region

  • cerebellum: 31 nTPM
  • cerebral cortex: 28 nTPM
  • thalamus: 28 nTPM
  • medulla oblongata: 26 nTPM
  • basal ganglia: 26 nTPM
  • hypothalamus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about XRCC1.

Disease | AllUniProt

Conditions XRCC1 is implicated in, by any mechanism.

  • Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26) MIM:617633

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 152 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.72
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of XRCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XRCC1 as an antibody target. Whether an autoantibody or antibody against XRCC1 could matter depends on whether native XRCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XRCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XRCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/XRCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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