EPHA6

Protein identityUniProt · HPA

UniProt accession

Q9UF33

Gene

EPHA6

Ensembl

ENSG00000080224

Chromosome

3

Canonical length

1036 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Mid piece

OverviewNCBI Gene

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1036 residues, UniProt reviewed canonical sequence.

>Q9UF33|EPHA6
     1  MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNNQVVLLDT TTVLGELGWK TYPLNGWDAI
    61  TEMDEHNRPI HTYQVCNVME PNQNNWLRTN WISRDAAQKI YVEMKFTLRD CNSIPWVLGT
   121  CKETFNLFYM ESDESHGIKF KPNQYTKIDT IAADESFTQM DLGDRILKLN TEIREVGPIE
   181  RKGFYLAFQD IGACIALVSV RVFYKKCPFT VRNLAMFPDT IPRVDSSSLV EVRGSCVKSA
   241  EERDTPKLYC GADGDWLVPL GRCICSTGYE EIEGSCHACR PGFYKAFAGN TKCSKCPPHS
   301  LTYMEATSVC QCEKGYFRAE KDPPSMACTR PPSAPRNVVF NINETALILE WSPPSDTGGR
   361  KDLTYSVICK KCGLDTSQCE DCGGGLRFIP RHTGLINNSV IVLDFVSHVN YTFEIEAMNG
   421  VSELSFSPKP FTAITVTTDQ DAPSLIGVVR KDWASQNSIA LSWQAPAFSN GAILDYEIKY
   481  YEKEHEQLTY SSTRSKAPSV IITGLKPATK YVFHIRVRTA TGYSGYSQKF EFETGDETSD
   541  MAAEQGQILV IATAAVGGFT LLVILTLFFL ITGRCQWYIK AKMKSEEKRR NHLQNGHLRF
   601  PGIKTYIDPD TYEDPSLAVH EFAKEIDPSR IRIERVIGAG EFGEVCSGRL KTPGKREIPV
   661  AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP NIIRLEGVVT KRSFPAIGVE AFCPSFLRAG
   721  FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV VEYMENGSLD SFLRKHDGHF TVIQLVGMLR
   781  GIASGMKYLS DMGYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI
   841  RWTAPEAIAY RKFSSASDAW SYGIVMWEVM SYGERPYWEM SNQDVILSIE EGYRLPAPMG
   901  CPASLHQLML HCWQKERNHR PKFTDIVSFL DKLIRNPSAL HTLVEDILVM PESPGEVPEY
   961  PLFVTVGDWL DSIKMGQYKN NFVAAGFTTF DLISRMSIDD IRRIGVILIG HQRRIVSSIQ
  1021  TLRLHMMHIQ EKGFHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPHA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

7.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.67

gnomAD missense Z

1.5

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon guidance
• ephrin receptor signaling pathway

Molecular functions

• ATP binding
• transmembrane-ephrin receptor activity

Cellular components

• dendrite
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Ephrin, ligand binding domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase, receptor class V, conserved site
• Sterile alpha motif domain
• Fibronectin type III
• Tyrosine-protein kinase, active site
• Galactose-binding-like domain superfamily
• Growth factor receptor cysteine-rich domain superfamily
• Protein kinase-like domain superfamily
• Tyrosine-protein kinase ephrin type A/B receptor-like
• Sterile alpha motif/pointed domain superfamily
• Immunoglobulin-like fold
• Ephrin receptor type-A /type-B
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• Ephrin, transmembrane domain
• Fibronectin type III superfamily
• Ephrin receptor tyrosine kinases
• Fibronectin type III domain
• SAM domain (Sterile alpha motif)
• Ephrin receptor ligand binding domain
• Tyrosine-protein kinase ephrin type A/B receptor-like
• Protein tyrosine and serine/threonine kinase
• Ephrin type-A receptor 2 transmembrane domain
• Ephrin cysteine rich domain
• Ephrin type-A receptor 6, ligand binding domain
• EPH-A6 , SAM domain

KeywordsUniProt

• ATP-binding
• Glycoprotein
• Kinase
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transferase
• Transmembrane
• Transmembrane helix
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of EPHA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPHA2