Seroatlas · Human Serome Atlas

MFGE8

Lactadherin

Also known as: BA46, EDIL1, hP47, HsT19888, MFG-E8, MFGM_HUMAN, OAcGD3S, SED1, SPAG10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q08431
Gene
MFGE8
Ensembl
ENSG00000140545
Chromosome
15
Canonical length
387 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q08431|MFGE8
     1  MPRPRLLAAL CGALLCAPSL LVALDICSKN PCHNGGLCEE ISQEVRGDVF PSYTCTCLKG
    61  YAGNHCETKC VEPLGLENGN IANSQIAASS VRVTFLGLQH WVPELARLNR AGMVNAWTPS
   121  SNDDNPWIQV NLLRRMWVTG VVTQGASRLA SHEYLKAFKV AYSLNGHEFD FIHDVNKKHK
   181  EFVGNWNKNA VHVNLFETPV EAQYVRLYPT SCHTACTLRF ELLGCELNGC ANPLGLKNNS
   241  IPDKQITASS SYKTWGLHLF SWNPSYARLD KQGNFNAWVA GSYGNDQWLQ VDLGSSKEVT
   301  GIITQGARNF GSVQFVASYK VAYSNDSANW TEYQDPRTGS SKIFPGNWDN HSHKKNLFET
   361  PILARYVRIL PVAWHNRIAL RLELLGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFGE8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
2,178 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 2,178 nTPM
  • heart muscle: 469 nTPM
  • endometrium: 382 nTPM
  • fallopian tube: 338 nTPM
  • skeletal muscle: 256 nTPM
  • adipose tissue: 228 nTPM

Single-cell type

  • breast lactating cells: 2,432 nCPM
  • vascular smooth muscle cells: 748 nCPM
  • decidual stromal cells: 646 nCPM
  • rod photoreceptor cells: 499 nCPM
  • breast secretory cells: 484 nCPM
  • pericytes: 441 nCPM

Immune cell

  • T-reg: 16 nTPM
  • NK-cell: 7.7 nTPM
  • basophil: 5.7 nTPM
  • naive CD4 T-cell: 4.7 nTPM
  • MAIT T-cell: 4.5 nTPM
  • memory CD4 T-cell: 4.3 nTPM

Brain region

  • medulla oblongata: 74 nTPM
  • cerebral cortex: 71 nTPM
  • choroid plexus: 70 nTPM
  • cerebellum: 67 nTPM
  • white matter: 66 nTPM
  • midbrain: 58 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MFGE8.

Disease | ImmuneIEDB

Conditions an epitope on MFGE8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
-0.36
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFGE8 as an antibody target. Whether an autoantibody or antibody against MFGE8 could matter depends on whether native MFGE8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFGE8 is annotated as secreted, so native MFGE8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • This protein has also been implicated in wound healing, autoimmune disease, and cancer.

Canonical record: https://seroatlas.com/gene/MFGE8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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