Seroatlas · Human Serome Atlas

GLB1L

Beta-galactosidase-1-like protein

Also known as: GLB1L_HUMAN, MGC10771

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWU2
Gene: GLB1L
Ensembl: ENSG00000163521
Chromosome: 2
Canonical length: 654 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

654 residues, UniProt reviewed canonical sequence.

>Q6UWU2|GLB1L
     1  MAPKKLSCLR SLLLPLSLTL LLPQADTRSF VVDRGHDRFL LDGAPFRYVS GSLHYFRVPR
    61  VLWADRLLKM RWSGLNAIQF YVPWNYHEPQ PGVYNFNGSR DLIAFLNEAA LANLLVILRP
   121  GPYICAEWEM GGLPSWLLRK PEIHLRTSDP DFLAAVDSWF KVLLPKIYPW LYHNGGNIIS
   181  IQVENEYGSY RACDFSYMRH LAGLFRALLG EKILLFTTDG PEGLKCGSLR GLYTTVDFGP
   241  ADNMTKIFTL LRKYEPHGPL VNSEYYTGWL DYWGQNHSTR SVSAVTKGLE NMLKLGASVN
   301  MYMFHGGTNF GYWNGADKKG RFLPITTSYD YDAPISEAGD PTPKLFALRD VISKFQEVPL
   361  GPLPPPSPKM MLGPVTLHLV GHLLAFLDLL CPRGPIHSIL PMTFEAVKQD HGFMLYRTYM
   421  THTIFEPTPF WVPNNGVHDR AYVMVDGVFQ GVVERNMRDK LFLTGKLGSK LDILVENMGR
   481  LSFGSNSSDF KGLLKPPILG QTILTQWMMF PLKIDNLVKW WFPLQLPKWP YPQAPSGPTF
   541  YSKTFPILGS VGDTFLYLPG WTKGQVWING FNLGRYWTKQ GPQQTLYVPR FLLFPRGALN
   601  KITLLELEDV PLQPQVQFLD KPILNSTSTL HRTHINSLSA DTLSASEPME LSGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLB1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

testis: 49 nTPM
fallopian tube: 22 nTPM
choroid plexus: 15 nTPM
parathyroid gland: 14 nTPM
kidney: 13 nTPM
epididymis: 11 nTPM

Single-cell type

late primary spermatocytes: 192 nCPM
early primary spermatocytes: 48 nCPM
respiratory ciliated cells: 45 nCPM
fallopian tube ciliated cells: 41 nCPM
epididymal efferent duct ciliated cells: 35 nCPM
ependymal cells: 29 nCPM

Immune cell

intermediate monocyte: 6.4 nTPM
non-classical monocyte: 5.4 nTPM
classical monocyte: 5 nTPM
myeloid DC: 2.1 nTPM
neutrophil: 1.9 nTPM
total PBMC: 1.7 nTPM

Brain region

choroid plexus: 37 nTPM
midbrain: 20 nTPM
medulla oblongata: 18 nTPM
white matter: 16 nTPM
pons: 15 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

galactose catabolic process

Molecular functions

beta-galactosidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLB1L as an antibody target. Whether an autoantibody or antibody against GLB1L could matter depends on whether native GLB1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLB1L is annotated as secreted, so native GLB1L circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GLB1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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