Seroatlas · Human Serome Atlas

ZZEF1

Zinc finger ZZ-type and EF-hand domain-containing protein 1

Also known as: FLJ10821, KIAA0399, ZZEF1_HUMAN, ZZZ4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43149
Gene: ZZEF1
Ensembl: ENSG00000074755
Chromosome: 17
Canonical length: 2961 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Predicted to act upstream of or within several processes, including glutamatergic synaptic transmission; regulation of peptidyl-tyrosine phosphorylation; and visual learning. Predicted to be located in cell surface; postsynapse; and presynaptic active zone. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

2961 residues, UniProt reviewed canonical sequence.

>O43149|ZZEF1
     1  MGNAPSHSSE DEAAAAGGEG WGPHQDWAAV SGTTPGPGVA APALPPAAAL LEPARLREAA
    61  AALLPTPPCE SLVSRHRGAL FRWLEERLGR GEESVTLEQF RELLEARGAG CSSEQFEEAF
   121  AQFDAEGDGT VDAENMLEAL KNSSGANLQG ELSHIIRQLQ ACSLVPGFTD IFSESKEGLD
   181  IHSSMILRFL HRNRLSSAVM PYPMLEHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLTRS
   241  PEMDKLKSVA KCYAYIETSS NSADIDKMTN GETSSYWQSD GSACSHWIRL KMKPDVVLRH
   301  LSIAVAATDQ SYMPQQVTVA VGRNASDLQE VRDVHIPSNV TGYVTLLENA NVSQLYVQIN
   361  IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW SLLTSLVTAS METNPAFVQT
   421  VLHNTQKALR HMPPLSLSPG STDFSTFLSP NVLEEVDSFL IRITSCCSTP EVELTLLAFA
   481  LARGSVAKVM SSLCTITDHL DTQYDASSLI LSMASVRQNL LLKYGKPLQL TLQACDVKGK
   541  EDKSGPENLL VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL
   601  VFAYNSSSDK FCAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD PIGWFELEEE
   661  WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLTIS GYLRPARAEA EQSVTCAHCR
   721  KDTEESVCGA TLLLRTLQFI QQLAHDLVQQ KESGLKYKSF LDFAGLDLQI FWNFYSKLKQ
   781  NPREECVSAQ TLLLQLLQSC FSVLQGDVLA ASEEEKAPIQ SPKGVEAAKE LYTHLCDVVD
   841  KVDGDSVPME ILKQEVRNTL LNGAAIFFPN RQTRRNHLFT MMNVTEQEHK QSLQLTFRSL
   901  CTYFSDKDPG GLLLLPEKND LAKMNISEVL AVMDTLVSVA ARECELLMLS GAPGEVGSVL
   961  FSLFWSVQGS LLSWCYLQLK STDSGAKDLA VDLIEKYVGQ FLASMRAILE SLFSQYSGKT
  1021  IVERLCNSVF SMAARQLVIF LLDFCTLDIP HCVLLREFSV LTELLKKLCS GPEGGLRKLD
  1081  VETWQQEQPV VLHTWTKESA HNYENNCHEV SVFVSPGATY FEVEFDDRCE TEKRYDYLEF
  1141  TDARGRKTRY DTKVGTDKWP KKVTFKAGPR LQFLFHSDSS HNEWGYKFTV TACGLPDVAV
  1201  SWGLDLQLLV SRLMGRLASQ CMALKSVRQL GSNMVVPQAK MALVLSSPLW KPVFRHQVCP
  1261  ELELEASWPT HPHRNSKEVK NIPDDPCRHF LLDFAQSEPA QNFCGPYSEL FKGFIQACRK
  1321  QAPKTDIVAG STIDQAVNAT FAALVYRTPD LYEKLQKYVN SGGKIALSEE FAQVYSLADG
  1381  IRIWMLEMKQ KSLMSLGNEA EEKHSSEATE VNPESLAKEC IEKSLLLLKF LPTGISSKES
  1441  CEKLETADET SHLQPLNKRQ RTSSVVEEHF QASVSPTEAA PPATGDQSPG LGTQPKLPSS
  1501  SGLPAADVSP ATAEEPLSPS TPTRRPPFTR GRLRLLSFRS MEEARLVPTV KEKYPVLKDV
  1561  MDFIKDQSLS HRSVVKVLSL RKAQAQSILE VLKITQHCAE SLGQPHCFHP PFILFLLELL
  1621  TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ LVLFLVKAVK GFSSLNDRSL LPALSCVQTA
  1681  LLHLLDMGWE PNDLAFFVDI QLPDLLMKMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM
  1741  DECQDGMFEA WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC
  1801  SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD DFDLCYGCYA
  1861  AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW LLFAALALYS AHLASAEDVD
  1921  GEKLDPQTRS SATTLRSQCM QLVGDCLMKA HQGKGLKALA LLGVLPDGDS SLEDQALPVT
  1981  VPTGASEEQL EKKAVQGAEL SEAGNGKRAV HEEIRPVDFK QRNKADKGVS LSKDPSCQTQ
  2041  ISDSPADASP PTGLPDAEDS EVSSQKPIEE KAVTPSPEQV FAECSQKRIL GLLAAMLPPL
  2101  KSGPTVPLID LEHVLPLMFQ VVISNAGHLN ETYHLTLGLL GQLIIRLLPA EVDAAVIKVL
  2161  SAKHNLFAAG DSSIVPDGWK TTHLLFSLGA VCLDSRVGLD WACSMAEILR SLNSAPLWRD
  2221  VIATFTDHCI KQLPFQLKHT NIFTLLVLVG FPQVLCVGTR CVYMDNANEP HNVIILKHFT
  2281  EKNRAVIVDV KTRKRKTVKD YQLVQKGGGQ ECGDSRAQLS QYSQHFAFIA SHLLQSSMDS
  2341  HCPEAVEATW VLSLALKGLY KTLKAHGFEE IRATFLQTDL LKLLVKKCSK GTGFSKTWLL
  2401  RDLEILSIML YSSKKEINAL AEHGDLELDE RGDREEEVER PVSSPGDPEQ KKLDPLEGLD
  2461  EPTRICFLMA HDALNAPLHI LRAIYELQMK KTDYFFLEVQ KRFDGDELTT DERIRSLAQR
  2521  WQPSKSLRLE EQSAKAVDTD MIILPCLSRP ARCDQATAES NPVTQKLISS TESELQQSYA
  2581  KQRRSKSAAL LHKELNCKSK RAVRDYLFRV NEATAVLYAR HVLASLLAEW PSHVPVSEDI
  2641  LELSGPAHMT YILDMFMQLE EKHEWEKILQ KVLQGCREDM LGTMALAACQ FMEEPGMEVQ
  2701  VRESKHPYNN NTNFEDKVHI PGAIYLSIKF DSQCNTEEGC DELAMSSSSD FQQDRHSFSG
  2761  SQQKWKDFEL PGDTLYYRFT SDMSNTEWGY RFTVTAGHLG RFQTGFEILK QMLSEERVVP
  2821  HLPLAKIWEW LVGVACRQTG HQRLKAIHLL LRIVRCCGHS DLCDLALLKP LWQLFTHMEY
  2881  GLFEDVTQPG ILLPLHRALT ELFFVTENRA QELGVLQDYL LALTTDDHLL RCAAQALQNI
  2941  AAISLAINYP NKATRLWNVE C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZZEF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

small intestine: 26 nTPM
skeletal muscle: 21 nTPM
bone marrow: 20 nTPM
colon: 18 nTPM
duodenum: 15 nTPM
thymus: 14 nTPM

Single-cell type

enterocytes: 381 nCPM
neutrophils: 314 nCPM
neutrophil progenitors: 214 nCPM
choroid plexus epithelial cells: 208 nCPM
cone photoreceptor cells: 197 nCPM
colonocytes: 193 nCPM

Immune cell

MAIT T-cell: 1 nTPM
neutrophil: 1 nTPM
non-classical monocyte: 1 nTPM
intermediate monocyte: 0.9 nTPM
gdT-cell: 0.8 nTPM
basophil: 0.7 nTPM

Brain region

choroid plexus: 46 nTPM
thalamus: 25 nTPM
medulla oblongata: 24 nTPM
pons: 23 nTPM
cerebral cortex: 23 nTPM
white matter: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZZEF1.

Disease | ImmuneIEDB

Conditions an epitope on ZZEF1 was assayed in.

stomach cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.83
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Zinc finger, ZZ-type
EF-hand domain
APC10/DOC domain
Galactose-binding-like domain superfamily
EF-hand domain pair
Zinc finger, ZZ-type superfamily
Zinc finger, ZZ type
Anaphase-promoting complex, subunit 10 (APC10)
Zinc finger ZZ-type and EF-hand domain-containing protein 1
ZZEF1, zinc finger, ZZ-type
Zinc finger ZZ-type and EF-hand domain-containing protein 1, APC10/DOC1-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZZEF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZZEF1 as an antibody target. Whether an autoantibody or antibody against ZZEF1 could matter depends on whether native ZZEF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZZEF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZZEF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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