Seroatlas · Human Serome Atlas

CNTNAP3B

Contactin-associated protein-like 3B

Also known as: CNT3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NU0
Gene: CNTNAP3B
Ensembl: ENSG00000154529
Chromosome: 9
Canonical length: 1288 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell adhesion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1288 residues, UniProt reviewed canonical sequence.

>Q96NU0|CNTNAP3B
     1  MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDSPLASALP RSSFSSSSEL SSSHGPGFSR
    61  LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY GSSDWVTSYL LMFSDGGRNW
   121  KQYRREESIW GFPGNTNADS VVHYRLQPPF EARFLRFLPL AWNPRGRIGM RIEVYGCAYK
   181  SEVVYFDGQS ALLYTLDKKP LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK
   241  LVFFLNSGNA KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
   301  SSNLDLNFEI SFGGILSPGR SRAFTRKSFH GCLENLYYNG VDVTELAKKH KPQILMMGNV
   361  SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT WNRAGHLLFG ELQRGSGSFV
   421  LFLKDGKLKL SLFQAGQSPR NVTAGAGLND GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA
   481  VLIDSGDTYY FGGCLGNSSG SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL
   541  QIDSCGITDR CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
   601  PSGLYYIDAD GSGPLGPFLV YCNMTADSAW TVVRHGGPDA VTLRGAPSGH PLSAVSFAYA
   661  AGAGQLRAAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW WVGRTNETHT SWGGSLPDAQ
   721  KCTCGLEGNC IDSQYYCNCD AGQNEWTSDT IVLSQKEHLP VTQIVMTDTG QPHSEADYTL
   781  GPLLCRGDKS FWNSASFNTE TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI
   841  RIELRAPTEV TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
   901  PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV TPGVEPGCAG
   961  HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI SAYFATGSSM TYHFQEHYTL
  1021  SENSSSLVSS LHRDVTLTRE MITLSFRTTR TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY
  1081  KLDRHQNPDA FTFDFKNMAD GQLHQVKINR EEAVVMVEVN QSAKKQVILS SGTEFNAVKS
  1141  LILGKVLEAA GADPDTRRAA TSGFTGCLSA VRFGCAAPLK AALRPSGPSR VTVRGHVAPM
  1201  ARCAAGAASG SPARELAPRL AGGAGRSGPV DEGEPLVNAD RRDSAVIGGV IAVEIFILLC
  1261  ITAIAIRIYQ QRKLRKENES KVSKKEEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNTNAP3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

breast: 9.6 nTPM
choroid plexus: 9.2 nTPM
adipose tissue: 8.4 nTPM
colon: 7.9 nTPM
esophagus: 7.2 nTPM
basal ganglia: 7 nTPM

Single-cell type

proximal tubule cells: 448 nCPM
bergmann glia: 261 nCPM
lymphatic endothelial cells: 163 nCPM
vascular endothelial cells: 116 nCPM
ependymal cells: 97 nCPM
renal collecting duct principal cells: 86 nCPM

Immune cell

neutrophil: 3.5 nTPM
eosinophil: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 22 nTPM
basal ganglia: 22 nTPM
hypothalamus: 18 nTPM
hippocampal formation: 18 nTPM
choroid plexus: 17 nTPM
cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -2.48
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Biological processes

cell adhesion

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNTNAP3B as an antibody target. Whether an autoantibody or antibody against CNTNAP3B could matter depends on whether native CNTNAP3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNTNAP3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNTNAP3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...