Seroatlas · Human Serome Atlas

GLB1L2

Beta-galactosidase-1-like protein 2

Also known as: GLBL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IW92
Gene
GLB1L2
Ensembl
ENSG00000149328
Chromosome
11
Canonical length
636 aa
Protein class
Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q8IW92|GLB1L2
     1  MTTWSLRRRP ARTLGLLLLV VLGFLVLRRL DWSTLVPLRL RHRQLGLQAK GWNFMLEDST
    61  FWIFGGSIHY FRVPREYWRD RLLKMKACGL NTLTTYVPWN LHEPERGKFD FSGNLDLEAF
   121  VLMAAEIGLW VILRPGPYIC SEMDLGGLPS WLLQDPGMRL RTTYKGFTEA VDLYFDHLMS
   181  RVVPLQYKRG GPIIAVQVEN EYGSYNKDPA YMPYVKKALE DRGIVELLLT SDNKDGLSKG
   241  IVQGVLATIN LQSTHELQLL TTFLFNVQGT QPKMVMEYWT GWFDSWGGPH NILDSSEVLK
   301  TVSAIVDAGS SINLYMFHGG TNFGFMNGAM HFHDYKSDVT SYDYDAVLTE AGDYTAKYMK
   361  LRDFFGSISG IPLPPPPDLL PKMPYEPLTP VLYLSLWDAL KYLGEPIKSE KPINMENLPV
   421  NGGNGQSFGY ILYETSITSS GILSGHVHDR GQVFVNTVSI GFLDYKTTKI AVPLIQGYTV
   481  LRILVENRGR VNYGENIDDQ RKGLIGNLYL NDSPLKNFRI YSLDMKKSFF QRFGLDKWSS
   541  LPETPTLPAF FLGSLSISST PCDTFLKLEG WEKGVVFING QNLGRYWNIG PQKTLYLPGP
   601  WLSSGINQVI VFEETMAGPA LQFTETPHLG RNQYIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLB1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • retina: 149 nTPM
  • choroid plexus: 44 nTPM
  • prostate: 32 nTPM
  • endometrium: 30 nTPM
  • colon: 26 nTPM
  • fallopian tube: 24 nTPM

Single-cell type

  • rod photoreceptor cells: 125 nCPM
  • decidual stromal cells: 46 nCPM
  • fallopian tube ciliated cells: 26 nCPM
  • respiratory ciliated cells: 26 nCPM
  • epididymal efferent duct ciliated cells: 25 nCPM
  • ependymal cells: 25 nCPM

Immune cell

  • gdT-cell: 3.2 nTPM
  • NK-cell: 3.1 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • MAIT T-cell: 1.2 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • naive CD4 T-cell: 0.9 nTPM

Brain region

  • choroid plexus: 40 nTPM
  • hippocampal formation: 26 nTPM
  • cerebral cortex: 24 nTPM
  • amygdala: 14 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.17
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLB1L2 as an antibody target. Whether an autoantibody or antibody against GLB1L2 could matter depends on whether native GLB1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLB1L2 is annotated as secreted, so native GLB1L2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GLB1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLB1L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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