Seroatlas · Human Serome Atlas

IFT25

Intraflagellar transport protein 25 homolog

Also known as: C1orf41, FAP232, HSPB11, HSPCO34, IFT25_HUMAN, PP25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y547
Gene: IFT25
Ensembl: ENSG00000081870
Chromosome: 1
Canonical length: 144 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be involved in kidney development; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>Q9Y547|IFT25
     1  MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE
    61  RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV
   121  SAFDHFASVH SVSAEGTVVS NLSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 91 nTPM
choroid plexus: 84 nTPM
fallopian tube: 75 nTPM
epididymis: 67 nTPM
lymph node: 58 nTPM
tonsil: 58 nTPM

Single-cell type

respiratory ciliated cells: 368 nCPM
fallopian tube ciliated cells: 319 nCPM
endometrial ciliated cells: 284 nCPM
cytotrophoblasts: 219 nCPM
oocytes: 207 nCPM
migrating cytotrophoblasts: 189 nCPM

Immune cell

basophil: 171 nTPM
eosinophil: 131 nTPM
T-reg: 122 nTPM
plasmacytoid DC: 122 nTPM
NK-cell: 110 nTPM
memory CD8 T-cell: 105 nTPM

Brain region

choroid plexus: 48 nTPM
white matter: 32 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 28 nTPM
spinal cord: 27 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coagulation factor 5/8, C-terminal domain
Galactose-binding-like domain superfamily
F5/8 type C domain
Intraflagellar transport protein 25

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT25 as an antibody target. Whether an autoantibody or antibody against IFT25 could matter depends on whether native IFT25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...