Seroatlas · Human Serome Atlas

RPS13

Small ribosomal subunit protein uS15

Also known as: RS13_HUMAN, S13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62277
Gene
RPS13
Ensembl
ENSG00000110700
Chromosome
11
Canonical length
151 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>P62277|RPS13
     1  MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV
    61  AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES
   121  RIHRLARYYK TKRVLPPNWK YESSTASALV A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
2,666 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,666 nTPM
  • bone marrow: 2,265 nTPM
  • skeletal muscle: 2,179 nTPM
  • pancreas: 2,007 nTPM
  • breast: 1,929 nTPM
  • lymph node: 1,898 nTPM

Single-cell type

  • esophageal suprabasal cells: 7,770 nCPM
  • esophageal apical cells: 6,622 nCPM
  • extravillous trophoblasts: 6,523 nCPM
  • esophageal basal cells: 6,267 nCPM
  • decidual stromal cells: 6,190 nCPM
  • migrating cytotrophoblasts: 5,789 nCPM

Immune cell

  • total PBMC: 6,032 nTPM
  • naive CD4 T-cell: 4,386 nTPM
  • memory B-cell: 3,735 nTPM
  • naive CD8 T-cell: 3,378 nTPM
  • naive B-cell: 3,260 nTPM
  • plasmacytoid DC: 3,202 nTPM

Brain region

  • white matter: 444 nTPM
  • spinal cord: 441 nTPM
  • medulla oblongata: 388 nTPM
  • hypothalamus: 365 nTPM
  • basal ganglia: 358 nTPM
  • thalamus: 353 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.88
gnomAD missense Z
1.77
DepMap mean gene effect
-1.63
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS13 as an antibody target. Whether an autoantibody or antibody against RPS13 could matter depends on whether native RPS13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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