Seroatlas · Human Serome Atlas

RPL13

Large ribosomal subunit protein eL13

Also known as: BBC1, D16S444E, L13, RL13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26373
Gene
RPL13
Ensembl
ENSG00000167526
Chromosome
16
Canonical length
211 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>P26373|RPL13
     1  MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP ASGPIRPIVR
    61  CPTVRYHTKV RAGRGFSLEE LRVAGIHKKV ARTIGISVDP RRRNKSTESL QANVQRLKEY
   121  RSKLILFPRK PSAPKKGDSS AEELKLATQL TGPVMPVRNV YKKEKARVIT EEEKNFKAFA
   181  SLRMARANAR LFGIRAKRAK EAAEQDVEKK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
4,875 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,875 nTPM
  • skin: 4,293 nTPM
  • pancreas: 4,150 nTPM
  • prostate: 2,774 nTPM
  • esophagus: 2,728 nTPM
  • vagina: 2,632 nTPM

Single-cell type

  • late spermatids: 18,275 nCPM
  • decidual stromal cells: 15,810 nCPM
  • esophageal suprabasal cells: 15,063 nCPM
  • esophageal apical cells: 14,191 nCPM
  • extravillous trophoblasts: 13,642 nCPM
  • pancreatic acinar cells: 13,194 nCPM

Immune cell

  • total PBMC: 13,779 nTPM
  • naive CD4 T-cell: 8,539 nTPM
  • naive B-cell: 8,251 nTPM
  • memory B-cell: 7,826 nTPM
  • MAIT T-cell: 7,024 nTPM
  • memory CD4 T-cell: 6,836 nTPM

Brain region

  • spinal cord: 936 nTPM
  • medulla oblongata: 860 nTPM
  • white matter: 844 nTPM
  • thalamus: 766 nTPM
  • amygdala: 725 nTPM
  • basal ganglia: 720 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL13.

Disease | AllUniProt

Conditions RPL13 is implicated in, by any mechanism.

  • Spondyloepimetaphyseal dysplasia, Isidor-Toutain type (SEMDIST) MIM:618728

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spondyloepimetaphyseal dysplasia, Isidor-Toutain type
  • Spondyloepimetaphyseal dysplasia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
gnomAD missense Z
-0.32
DepMap mean gene effect
-2.26
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein eL13
  • Large ribosomal subunit protein eL13, conserved site
  • Ribosomal protein L13e

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL13 as an antibody target. Whether an autoantibody or antibody against RPL13 could matter depends on whether native RPL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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