Seroatlas · Human Serome Atlas

RPL23A

Large ribosomal subunit protein uL23

Also known as: L23A, RL23A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62750
Gene
RPL23A
Ensembl
ENSG00000198242
Chromosome
17
Canonical length
156 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli fibrillar center,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>P62750|RPL23A
     1  MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK TLRLRRQPKY
    61  PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV DVKANKHQIK QAVKKLYDID
   121  VAKVNTLIRP DGEKKAYVRL APDYDALDVA NKIGII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL23A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
3,492 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,492 nTPM
  • skin: 2,162 nTPM
  • skeletal muscle: 2,006 nTPM
  • cervix: 1,966 nTPM
  • pancreas: 1,768 nTPM
  • blood vessel: 1,764 nTPM

Single-cell type

  • extravillous trophoblasts: 7,438 nCPM
  • esophageal suprabasal cells: 6,873 nCPM
  • decidual stromal cells: 6,539 nCPM
  • esophageal basal cells: 6,271 nCPM
  • migrating cytotrophoblasts: 6,254 nCPM
  • ovarian stromal cells: 5,999 nCPM

Immune cell

  • total PBMC: 7,349 nTPM
  • memory B-cell: 6,820 nTPM
  • naive CD4 T-cell: 6,334 nTPM
  • naive CD8 T-cell: 5,971 nTPM
  • MAIT T-cell: 5,939 nTPM
  • memory CD4 T-cell: 5,807 nTPM

Brain region

  • spinal cord: 441 nTPM
  • white matter: 385 nTPM
  • thalamus: 385 nTPM
  • basal ganglia: 359 nTPM
  • medulla oblongata: 347 nTPM
  • pons: 336 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
0.24
DepMap mean gene effect
-2.08
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL23A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL23A as an antibody target. Whether an autoantibody or antibody against RPL23A could matter depends on whether native RPL23A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL23A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL23A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL23A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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