Seroatlas · Human Serome Atlas

RPL11

Large ribosomal subunit protein uL5

Also known as: L11, RL11_HUMAN, uL5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62913
Gene
RPL11
Ensembl
ENSG00000142676
Chromosome
1
Canonical length
178 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>P62913|RPL11
     1  MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF
    61  GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS DTGNFGFGIQ EHIDLGIKYD
   121  PSIGIYGLDF YVVLGRPGFS IADKKRRTGC IGAKHRISKE EAMRWFQQKY DGIILPGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
2,010 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,010 nTPM
  • tonsil: 1,726 nTPM
  • breast: 1,684 nTPM
  • pancreas: 1,472 nTPM
  • skin: 1,168 nTPM
  • thymus: 1,137 nTPM

Single-cell type

  • esophageal suprabasal cells: 11,803 nCPM
  • esophageal basal cells: 10,127 nCPM
  • extravillous trophoblasts: 9,938 nCPM
  • decidual stromal cells: 9,128 nCPM
  • esophageal apical cells: 7,912 nCPM
  • migrating cytotrophoblasts: 7,598 nCPM

Immune cell

  • total PBMC: 5,466 nTPM
  • naive CD4 T-cell: 3,390 nTPM
  • memory B-cell: 3,273 nTPM
  • naive B-cell: 2,824 nTPM
  • memory CD4 T-cell: 2,601 nTPM
  • naive CD8 T-cell: 2,584 nTPM

Brain region

  • medulla oblongata: 342 nTPM
  • white matter: 338 nTPM
  • spinal cord: 317 nTPM
  • hypothalamus: 308 nTPM
  • thalamus: 288 nTPM
  • basal ganglia: 283 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL11.

Disease | AllUniProt

Conditions RPL11 is implicated in, by any mechanism.

Disease | GeneticClinVar

48 pathogenic / likely-pathogenic of 239 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
1.69
DepMap mean gene effect
-2.34
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein uL5
  • Large ribosomal subunit protein uL5, conserved site
  • Large ribosomal subunit protein uL5 domain superfamily
  • Large ribosomal subunit protein uL5, C-terminal
  • Large ribosomal subunit protein uL5, N-terminal
  • Large ribosomal subunit protein uL5, eukaryota/archaea
  • Ribosomal protein L5
  • ribosomal L5P family C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL11 as an antibody target. Whether an autoantibody or antibody against RPL11 could matter depends on whether native RPL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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